Sox2 Antibody (E-4): sc-365823
- Sox2 Antibody (E-4) is a mouse monoclonal IgG1 κ Sox2 antibody, cited in 359 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 170-201 within an internal region of Sox-2 of human origin
- Sox2 Antibody (E-4) is recommended for detection of Sox-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and bovine
- Anti-Sox2 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-365823 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sox2 Antibody (E-4) for WB and IHC(P) applications. These reagents are now offered in bundles with Sox2 Antibody (E-4) (see ordering information below).
Sox-2 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect human Sox-2 with exceptional precision across multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sox-2 monoclonal antibody (E-4) targets a meticulously mapped epitope within amino acids 170-201 of the internal region of human Sox-2, ensuring robust and reliable binding. Anti-Sox-2 antibody (E-4) demonstrates broad species reactivity, effectively recognizing Sox-2 from mouse, rat, and human origins, as well as other species such as equine, canine, and bovine, making this tool versatile for diverse research needs. Sox-2, also called lcc, ysb, and Sox2, is a pivotal transcription factor localized primarily in the nucleus, where Sox-2 plays a crucial role in maintaining pluripotency and self-renewal of embryonic stem cells, thereby governing cell fate decisions and orchestrating key developmental processes. Sox-2′s nuclear localization is essential for regulating gene expression, influencing pathways fundamental to embryonic development and maintenance of stem cell populations. Dysregulation of Sox-2 has been implicated in various developmental disorders and diseases, including certain cancers, underscoring Sox-2′s significance in both normal physiology and pathological conditions. Sox-2 monoclonal antibody (E-4) enables researchers to effectively investigate expression patterns, functional roles, and regulatory mechanisms of Sox-2, facilitating advancements in developmental biology, regenerative medicine, and disease research. Anti-Sox-2 antibody (E-4) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing flexibility and convenience for a wide range of experimental applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sox2 Antibody (E-4) References:
- Identification of a novel Sry-related gene and its germ cell-specific expression. | Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
- Roles of Sox factors in neural determination: conserved signaling in evolution? | Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
- Ancestry and diversity of the HMG box superfamily. | Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
- Sox10, a novel transcriptional modulator in glial cells. | Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
- Characterisation and mapping of the human SOX14 gene. | Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sox2 Antibody (E-4) | sc-365823 | 200 µg/ml | $322.00 | |||
Sox2 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-529482 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sox2 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-522383 | 200 µg Ab, 40 µg BP | $361.00 | |||
Sox2 Antibody (E-4): m-IgG1 BP-HRP Bundle | sc-543536 | 200 µg Ab; 20 µg BP | $361.00 | |||
Sox2 Antibody (E-4) X | sc-365823 X | 200 µg/0.1 ml | $322.00 | |||
Sox2 Antibody (E-4) AC | sc-365823 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Sox2 Antibody (E-4) HRP | sc-365823 HRP | 200 µg/ml | $322.00 | |||
Sox2 Antibody (E-4) FITC | sc-365823 FITC | 200 µg/ml | $336.00 | |||
Sox2 Antibody (E-4) PE | sc-365823 PE | 200 µg/ml | $349.00 | |||
Sox2 Antibody (E-4) Alexa Fluor® 488 | sc-365823 AF488 | 200 µg/ml | $364.00 | |||
Sox2 Antibody (E-4) Alexa Fluor® 546 | sc-365823 AF546 | 200 µg/ml | $364.00 | |||
Sox2 Antibody (E-4) Alexa Fluor® 594 | sc-365823 AF594 | 200 µg/ml | $364.00 | |||
Sox2 Antibody (E-4) Alexa Fluor® 647 | sc-365823 AF647 | 200 µg/ml | $364.00 | |||
Sox2 Antibody (E-4) Alexa Fluor® 680 | sc-365823 AF680 | 200 µg/ml | $364.00 | |||
Sox2 Antibody (E-4) Alexa Fluor® 790 | sc-365823 AF790 | 200 µg/ml | $364.00 | |||
Sox2 (E-4) Neutralizing Peptide | sc-365823 P | 100 µg/0.5 ml | $69.00 |