SLA2 Antibody (E-2): sc-398928

SLA2 Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects SLA2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SLA2, also known as Src-like-adapter 2 or C20orf156, is a 261 amino acid protein that exists in four alternatively spliced isoforms, which can localize to either the cytoplasm or the cell membrane, featuring one SH2 domain and one SH3 domain. SLA2 plays a crucial role as an adaptor protein that negatively regulates T-cell receptor (TCR) signaling, thereby inhibiting T-cell activation, which is vital for maintaining immune homeostasis and preventing overactive immune responses that could lead to autoimmune diseases. SLA2 interacts with Zap-70, a key player in T-cell signaling, and is subject to post-translational phosphorylation, which can modulate its activity and interactions. The gene encoding SLA2 is located on human chromosome 20, a chromosome that comprises approximately 2% of the human genome and contains nearly 63 million bases encoding over 600 genes, some of which are implicated in various neurological and genetic disorders. anti-SLA2 antibody (E-2) is an essential tool for researchers studying T-cell signaling and immune regulation.

The preferred SLA2 antibody is SLA2 Antibody (E-8): sc-398134.