SGK Inhibitors zur funktionellen Analyse zellulärer Antworten auf SGK
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its role in signal transduction pathways and high frequency of mutations in human malignancies. The founding members of the Ras family (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The mammalian Rho proteins (Rho A, B, C, 6, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Three Rho-related GTPases Rnd1 (Rho 6), Rnd2 (Rho 7), and Rnd3 (Rho 8 or Rho E) form a distinct branch of the Rho family since they differ from other Rho proteins in size, charge, and biochemical properties. Rnd proteins are likely to be farnesylated, and appear to be constitutively in the activated GTP-bound form. Rnd proteins act as negative regulators of Actin assembly and of cell adhesion. Rnd2 binds to SgK223 (sugen kinase 223) in a GTP-dependent manner. Rnd2-bound SgK223 stimulates Rho A activity and induces cell contraction to regulate neurite outgrowth.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
What is the recommended secondary for Sgk223 (O67): sc-130491 monoclonal antibody?
Gefragt von: Cweed
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here:
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