SerpinA9 Antibody (913G2V): sc-517654

SerpinA9 Antibody (913G2V) is a mouse monoclonal IgM antibody that detects SerpinA9 protein of human origin by western blotting (WB). Anti-SerpinA9 antibody (913G2V) is available as a non-conjugated format, specifically designed to provide reliable detection of this important protein. SerpinA9, also known as serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9, is a 417 amino acid protein that plays a crucial role as a protease inhibitor, primarily inhibiting trypsin and trypsin-like serine proteases in vitro, while also exhibiting lower efficiency against plasmin and thrombin. SerpinA9 shows high expression in normal germinal center B-cells and involvement in B-cell-derived malignancies, making SerpinA9 a key player in immune regulation and potential therapeutic target. SerpinA9 gene is located within a gene cluster on chromosome 14q32.1, spanning over 370 kb and encompassing ten additional members of the Serpin superfamily, which share significant sequence similarity and a common gene structure characterized by one untranslated exon and four coding exons. This evolutionary relationship suggests that the Serpin superfamily arose from a common ancestral gene through duplication events. SerpinA9 exists in seven alternatively spliced isoforms and is conserved across several species, including chimpanzee, canine, mouse, rat, and zebrafish, highlighting SerpinA9′s fundamental biological importance.

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SerpinA9 Antibody (913G2V) References:

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2. Differential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids.  |  Rollini, P. and Fournier, RE. 2000. Nucleic Acids Res. 28: 1767-77. PMID: 10734196
3. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.  |  Namciu, SJ., et al. 2004. Mamm Genome. 15: 162-78. PMID: 15014966
4. Organization and expression of the human serpin gene cluster at 14q32.1.  |  Marsden, MD. and Fournier, RE. 2005. Front Biosci. 10: 1768-78. PMID: 15769666
5. Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2.  |  Seixas, S., et al. 2007. Mol Biol Evol. 24: 587-98. PMID: 17135331
6. Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.  |  Silverman, GA., et al. 2010. J Biol Chem. 285: 24299-305. PMID: 20498369