SAPK4 Antibody (E-3): sc-271292

SAPK4 Antibody (E-3) is a mouse monoclonal IgG1 antibody that detects SAPK4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAPK4, also known as p38δ, is a member of the mitogen-activated protein kinase (MAPK) family, which plays a crucial role in cellular responses to stress and inflammation. SAPK4 is primarily located in the cytoplasm, where activation occurs by various stimuli, including cytokines and environmental stressors, leading to phosphorylation of downstream targets that regulate gene expression and cell survival. SAPK4′s cytoplasmic localization allows for rapid signaling responses to stress, enabling cells to adapt to changing conditions. SAPK4 interacts with other proteins, such as MKK6, which phosphorylates SAPK4, further emphasizing SAPK4′s role in the MAPK signaling cascade. A unique TGY phosphorylation motif distinguishes SAPK4 from other MAPK family members, highlighting specialized functions in cellular signaling pathways. anti-SAPK4 antibody (E-3) serves as an essential tool for researchers studying the intricate mechanisms of stress response and inflammation in various biological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SAPK4 Antibody (E-3) References:

1. Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation.  |  Johnstone, ED., et al. 2005. Biol Reprod. 73: 1282-8. PMID: 16120828
2. Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β.  |  Liu, H., et al. 2011. Cardiovasc Res. 89: 119-28. PMID: 20724307
3. p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure.  |  Che, X., et al. 2013. Biochim Biophys Acta. 1833: 2083-91. PMID: 23639288
4. Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition.  |  Abdelfadil, E., et al. 2013. Am J Chin Med. 41: 683-96. PMID: 23711149
5. Both classic Gs-cAMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β/CREB signal pathways mediate exenatide-stimulated expression of M2 microglial markers.  |  Wu, HY., et al. 2018. J Neuroimmunol. 316: 17-22. PMID: 29249556
6. Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same.  |  Sahu, V., et al. 2019. Cancer Res Treat. 51: 313-325. PMID: 29747487
7. Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11.  |  Li, Y., et al. 2019. Biosci Rep. 39: PMID: 31123170
8. p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice.  |  Liu, Z., et al. 2018. Cell Stress. 2: 311-324. PMID: 31225455
9. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation.  |  Donoghue, C., et al. 2020. Eur J Med Chem. 201: 112451. PMID: 32634680
10. The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.  |  Wang, S., et al. 2021. BMC Endocr Disord. 21: 235. PMID: 34814904

The preferred SAPK4 antibody is SAPK4 Antibody (E-7): sc-46678.