SAP 97 Antibody (2D11): sc-9961

SAP 97 Antibody (2D11) is a mouse monoclonal IgG1 kappa light chain antibody that detects SAP 97 protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. SAP 97 Antibody (2D11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SAP 97 protein, also known as DLG1, plays a crucial role in synaptic signaling and is a member of the membrane-associated guanylate kinase (MAGUK) family, which is essential for maintaining the structure and function of synapses. Located at the membrane-cytoskeleton interface, SAP 97 is involved in organizing protein complexes that facilitate intracellular signaling pathways, thereby influencing synaptic plasticity and neuronal communication. SAP 97′s interaction with other proteins, such as the tumor suppressor APC, highlights SAP 97′s potential role in regulating cell growth and maintaining cellular integrity. The identification of SAP 97 as a key player in synaptic function underscores SAP 97′s importance in neurobiology and relevance in studies of neurodegenerative diseases and synaptic disorders.

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SAP 97 Antibody (2D11) References:

1. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.  |  Cho, KO., et al. 1992. Neuron. 9: 929-42. PMID: 1419001
2. Differential expression of human Dlg in cervical intraepithelial neoplasias.  |  Lin, HT., et al. 2004. Gynecol Oncol. 93: 422-8. PMID: 15099956
3. Emerging role of the scaffolding protein Dlg1 in vesicle trafficking.  |  Walch, L. 2013. Traffic. 14: 964-73. PMID: 23829493
4. Tumor-suppressor genes of Drosophila melanogaster.  |  Gateff, E. and Mechler, BM. 1989. Crit Rev Oncog. 1: 221-45. PMID: 2518684
5. Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology.  |  Marziali, F., et al. 2019. Biol Chem. 400: 699-710. PMID: 30517074
6. A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.  |  Castillo-Azofeifa, D., et al. 2023. Cell Stem Cell. 30: 188-206.e6. PMID: 36640764
7. DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2.  |  Rezi, CK., et al. 2024. EMBO Rep. 25: 3040-3063. PMID: 38849673
8. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein.  |  Müller, BM., et al. 1995. J Neurosci. 15: 2354-66. PMID: 7891172
9. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.  |  Lue, RA., et al. 1994. Proc Natl Acad Sci U S A. 91: 9818-22. PMID: 7937897
10. ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions.  |  Woods, DF. and Bryant, PJ. 1993. Mech Dev. 44: 85-9. PMID: 8155583
11. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.  |  Matsumine, A., et al. 1996. Science. 272: 1020-3. PMID: 8638125
12. Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.  |  Makino, K., et al. 1997. Oncogene. 14: 2425-33. PMID: 9188857

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SAP 97 Antibody (2D11) has 63 citations in a variety of scientific publications.

Primary antibodies like Anti-SAP 97 Antibody (2D11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SAP 97 Antibody (2D11) Specifications

Alternate Product Name: DLG1

Product Clone Name: 2D11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-229

Epitope Target: SAP 97

Epitope Species: human

Product Reactivity/Detection: SAP 97 (also designated Dlg1)

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 63 citations in various scientific publications

Available Conjugates/Forms for SAP 97 Antibody (2D11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin