RXRβ₁ Antibody (A-1): sc-376301

RXRβ1 Antibody (A-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects RXR beta 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RXRβ1 antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RXR beta 1 protein plays a crucial role in regulating gene expression as a member of the retinoid X receptor family, which is essential for mediating retinoic acid effects, a derivative of vitamin A. RXR beta 1 protein is primarily located in the nucleus, where RXR beta 1 functions as a transcription factor that dimerizes with other nuclear receptors, such as retinoic acid receptors (RARs), to regulate target gene expression involved in processes like cell differentiation, growth, and apoptosis. RXR beta 1′s ability to form heterodimers with RARs and other nuclear receptors underscores RXR beta 1′s importance in various physiological processes and potential implications in developmental biology and cancer research. RXRβ1 monoclonal antibody (A-1) in experiments can provide valuable insights into functional dynamics of RXR beta 1 protein and interactions within the cellular environment.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RXRβ₁ Antibody (A-1) References:

1. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.  |  Levin, AA., et al. 1992. Nature. 355: 359-61. PMID: 1309942
2. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.  |  Heyman, RA., et al. 1992. Cell. 68: 397-406. PMID: 1310260
3. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.  |  Yang, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 3559-63. PMID: 1850832
4. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily.  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
5. A functional retinoic acid receptor encoded by the gene on human chromosome 12.  |  Ishikawa, T., et al. 1990. Mol Endocrinol. 4: 837-44. PMID: 2172793
6. MDM2-Mediated Ubiquitination of RXRβ Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis.  |  Zeng, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35628577
7. Phase separation propensity of the intrinsically disordered AB region of human RXRβ.  |  Sołtys, K. and Ożyhar, A. 2023. Cell Commun Signal. 21: 92. PMID: 37143076
8. Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic acid induced activation of the retinoid X receptor beta homodimer.  |  Medin, JA., et al. 1994. Mol Cell Endocrinol. 105: 27-35. PMID: 7821715
9. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
10. Differential effect of IFN-alpha and IFN-gamma on phosphorylation of p65 and p50 (rel) in the K562 cell line: implications for altered interaction with RXR beta.  |  Chatterjee, M., et al. 1996. Cytokine. 8: 357-64. PMID: 8726663
11. Potential role of NF-kB and RXR beta like proteins in interferon induced HLA class I and beta globin gene transcription in K562 erythroleukaemia cells.  |  Moitreyee, CK., et al. 1998. Mol Cell Biochem. 178: 103-12. PMID: 9546588
12. Characterization of mouse retinoid X receptor (RXR)-beta gene promoter: negative regulation by tumor necrosis factor (TNF)-alpha.  |  Sugawara, A., et al. 1998. Endocrinology. 139: 3030-3. PMID: 9607817

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RXRβ₁ Antibody (A-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RXRβ₁ Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RXRβ₁ Antibody (A-1) Specifications

Alternate Product Name: RXRβ1

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-31

Epitope Target: RXRβ1

Epitope Species: mouse

Product Reactivity/Detection: RXRβ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RXRβ₁ Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred RXRα/β/γ antibody is RXRα/β/γ Antibody (F-1): sc-46659.