Ribosomal Protein L19 Antibody (K-12): sc-100830

Ribosomal Protein L19 Antibody (K-12) is a mouse monoclonal IgG2a lambda light chain antibody that detects Ribosomal Protein L19 (RPL19) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RPL19 antibody (K-12) is available as the non-conjugated form. RPL19, a 196 amino acid protein, is an essential component of the 60S ribosomal subunit, which plays a critical role in protein synthesis within the cytoplasm. Proper functioning of ribosomes is vital for cellular health, as ribosomes translate messenger RNA into polypeptide chains, ultimately forming proteins crucial for various cellular functions. RPL19 (K-12) monoclonal antibody belongs to the L19e family of ribosomal proteins and has been implicated in translation regulation, with expression levels upregulated in certain cancers, including breast cancer, where RPL19 serves as a prognostic marker for prostate cancer. Multiple processed pseudogenes scattered throughout the genome highlight the complexity of RPL19 regulation and evolutionary significance. Anti-RPL19 antibody (K-12) is a valuable tool for researchers studying ribosomal function and cancer biology implications.

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Ribosomal Protein L19 Antibody (K-12) References:

1. Identification of genes differentially expressed in breast cancer cell line SKBR3: potential identification of new prognostic biomarkers.  |  Leirdal, M., et al. 2004. Int J Mol Med. 14: 217-22. PMID: 15254768
2. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome.  |  Feo, S., et al. 1992. Genomics. 13: 201-7. PMID: 1577483
3. Housekeeping gene expression during fetal brain development in the rat-validation by semi-quantitative RT-PCR.  |  Al-Bader, MD. and Al-Sarraf, HA. 2005. Brain Res Dev Brain Res. 156: 38-45. PMID: 15862626
4. Ribosomal protein l19 is a prognostic marker for human prostate cancer.  |  Bee, A., et al. 2006. Clin Cancer Res. 12: 2061-5. PMID: 16609016
5. Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer.  |  Huang, CJ., et al. 2008. J Cell Mol Med. 12: 1936-43. PMID: 18266979
6. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma.  |  Kuroda, K., et al. 2010. Cancer Sci. 101: 46-53. PMID: 19799608
7. Ribosomal protein L19 overexpression activates the unfolded protein response and sensitizes MCF7 breast cancer cells to endoplasmic reticulum stress-induced cell death.  |  Hong, M., et al. 2014. Biochem Biophys Res Commun. 450: 673-8. PMID: 24950402
8. Alterations in ribosomal protein L19 that decrease the fidelity of translation.  |  VanNice, J., et al. 2016. Biochimie. 128-129: 122-6. PMID: 27477481
9. A strategy to detect and isolate an intron-containing gene in the presence of multiple processed pseudogenes.  |  Davies, B., et al. 1989. Proc Natl Acad Sci U S A. 86: 6691-5. PMID: 2771953
10. Ribosomal protein gene sequences map to human chromosomes 5, 8, and 17.  |  Nakamichi, NN., et al. 1986. Somat Cell Mol Genet. 12: 225-36. PMID: 3459254
11. The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein.  |  Chan, YL., et al. 1987. J Biol Chem. 262: 1111-5. PMID: 3542997
12. The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region.  |  Davies, B. and Fried, M. 1995. Genomics. 25: 372-80. PMID: 7789970

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein L19 Antibody (K-12) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein L19 Antibody (K-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein L19 Antibody (K-12) Specifications

Alternate Product Name: Ribosomal Protein L19

Product Clone Name: K-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids: 1-101

Epitope Target: Ribosomal Protein L19

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein L19

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein L19 Antibody (K-12): N/A