Molecular structure of Ramoplanin, CAS Number: 76168-82-6
Ramoplanin (CAS 76168-82-6)
Alternate Names:
A 16686; Antibiotic A 16686
Application:
Ramoplanin is an antimicrobial that is effective against gram-positive bacteria
CAS Number:
76168-82-6
Molecular Weight:
2554.1
Molecular Formula:
C119H154ClN21O40
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ramoplanin, a potent cyclic lipoglycodepsipeptide antibiotic, has been reported to be active against aerobic and anaerobic gram-positive bacteria. Mechanistic studies show that Ramoplanin prevents cell wall peptidoglygan formation and further enzymatic processing via binding to lipid II, a key intermediate moeity. Ramoplanin has also displayed a low affinity for Lipid I, a substrate for the MurG step of cell wall formation.
Ramoplanin (CAS 76168-82-6) References
- Vancomycin, teicoplanin, and ramoplanin: synthetic and mechanistic studies. | Boger, DL. 2001. Med Res Rev. 21: 356-81. PMID: 11579438
- Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. | Hu, Y., et al. 2003. J Am Chem Soc. 125: 8736-7. PMID: 12862463
- Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice. | Stiefel, U., et al. 2004. Antimicrob Agents Chemother. 48: 2144-8. PMID: 15155213
- Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. | Chen, L., et al. 2004. J Am Chem Soc. 126: 7462-3. PMID: 15198592
- Ramoplanin: a lipoglycodepsipeptide antibiotic. | Farver, DK., et al. 2005. Ann Pharmacother. 39: 863-8. PMID: 15784805
- The mechanism of action of ramoplanin and enduracidin. | Fang, X., et al. 2006. Mol Biosyst. 2: 69-76. PMID: 16880924
- Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. | Fulco, P. and Wenzel, RP. 2006. Expert Rev Anti Infect Ther. 4: 939-45. PMID: 17181409
- Ramoplanin imaging conjugates--synthesis and evaluation. | Sheikh, S., et al. 2014. Med Chem. 10: 18-26. PMID: 23646874
- Production of ramoplanin analogues by genetic engineering of Actinoplanes sp. | Pan, HX., et al. 2013. Biotechnol Lett. 35: 1685-92. PMID: 23801115
- Unmodified gold nanoparticles as a simple colorimetric probe for ramoplanin detection. | Teepoo, S., et al. 2013. Talanta. 117: 518-22. PMID: 24209375
- Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. | Cheng, M., et al. 2014. Antimicrob Agents Chemother. 58: 6819-27. PMID: 25182650
- Ambush of Clostridium difficile spores by ramoplanin: activity in an in vitro model. | Kraus, CN., et al. 2015. Antimicrob Agents Chemother. 59: 2525-30. PMID: 25691641
- Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29. | Wu, MC., et al. 2015. Microbiology (Reading). 161: 1338-47. PMID: 25878261
- Investigation of halogenation during the biosynthesis of ramoplanin in Actinoplanes sp. ATCC33076. | Chen, JS., et al. 2016. Appl Microbiol Biotechnol. 100: 289-98. PMID: 26446384
- Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes. | de la Cruz, M., et al. 2017. Front Microbiol. 8: 343. PMID: 28321210
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ramoplanin, 5 mg | sc-253424A | 5 mg | $104.00 | |||
Ramoplanin, 250 mg | sc-253424 | 250 mg | $467.00 |