Molecular structure of (R/S)-Colchicine, CAS Number: 209810-38-8
(R/S)-Colchicine (CAS 209810-38-8)
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Alternate Names:
N-[5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; (±)-Colchicine
Application:
(R/S)-Colchicine is a racemic colchicine mixture
CAS Number:
209810-38-8
Molecular Weight:
399.44
Molecular Formula:
C22H25NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
(R/S)-Colchicine is racemic colchicine. (R/S)-Colchicine acts as an inhibitor of certain enzymes, such as proteases, phosphatases, and kinases. It may act to interact with the active sites of these enzymes, which results in the inhibition of their activity.
(R/S)-Colchicine (CAS 209810-38-8) References
- Analysis of the colchicine-binding site of beta-tubulin. | Burns, RG. 1992. FEBS Lett. 297: 205-8. PMID: 1544399
- Colchicine affects cell motility, pattern formation and stalk cell differentiation in Dictyostelium by altering calcium signaling. | Poloz, Y. and O'Day, DH. 2012. Differentiation. 83: 185-99. PMID: 22381626
- Colchicine: an old wine in a new bottle? | Roubille, F., et al. 2013. Antiinflamm Antiallergy Agents Med Chem. 12: 14-23. PMID: 23286287
- The effects of colchicine in mammalian brain from rodents to rhesus monkeys. | Dasheiff, RM. and Ramirez, LF. 1985. Brain Res. 357: 47-67. PMID: 2412662
- Colchicine derivative as a potential anti-glioma compound. | Fang, KM., et al. 2015. J Neurooncol. 124: 403-12. PMID: 26239968
- Electrophilicities and Protein Covalent Binding of Demethylation Metabolites of Colchicine. | Guo, X., et al. 2016. Chem Res Toxicol. 29: 296-302. PMID: 26845511
- Colchicine: an affordable anti-inflammatory agent for atherosclerosis. | Thompson, PL. and Nidorf, SM. 2018. Curr Opin Lipidol. 29: 467-473. PMID: 30320614
- Fatal colchicine intoxication by ingestion of Gloriosa superba tubers. | Gunasekaran, K., et al. 2019. BMJ Case Rep. 12: PMID: 31101749
- Inflammation May be the Future of Cardiovascular Risk Reduction: Does Colchicine have a Current Indication? | Whayne, TF. 2021. Am J Cardiovasc Drugs. 21: 1-10. PMID: 32356107
- Total Biosynthesis of the Tubulin-Binding Alkaloid Colchicine. | Nett, RS. and Sattely, ES. 2021. J Am Chem Soc. 143: 19454-19465. PMID: 34780686
- Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective. | Wang, J., et al. 2022. Drug Discov Today. 27: 759-776. PMID: 34890803
- A Hypothesis Regarding Neurosecretory Inhibition of Stress Mediators by Colchicine in Preventing Stress-Induced Familial Mediterranean Fever Attacks. | Korkmaz, C., et al. 2022. Front Immunol. 13: 834769. PMID: 35251026
- Colchicine as a Modulator of Platelet Function: A Systematic Review. | Reddel, CJ., et al. 2022. Semin Thromb Hemost. 48: 552-567. PMID: 35882248
- Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model. | Yue, H., et al. 2022. Biomed Pharmacother. 154: 113573. PMID: 35987161
- Colchicine increases intestinal toxic load by disturbing fecal metabolome homeostasis in mice. | Shi, Y., et al. 2022. Chem Biol Interact. 368: 110193. PMID: 36179773
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R/S)-Colchicine, 50 mg | sc-394137 | 50 mg | $380.00 |