PPIase-Parvulin Inhibitor (CAS 64005-90-9)
Alternative Namen:
PiB; HIC 016C; Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
Anwendungen
PPIase-Parvulin Inhibitor is a Pin1/Pin4 PPIase activity inhibitor
CAS Nummer:
64005-90-9
Reinheit:
≥95%
Molekulargewicht:
438.4
Summenformel:
C22H18N2O8
Ergänzende Informationen:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
PPIase-Parvulin Inhibitor is a cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. PPIase-Parvulin Inhibitor causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Pin4 PPIase (peptidyl prolyl cis-trans isomerase) activity. It does not bind to DNA or functions as a topoisomerase I inhibitor.
Literaturhinweise
1. Uchida, Takafumi., et al., 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chemistry & biology. 10(1): 15-24. PMID: 12573694
Aggregatzustand
:
Solid
Löslichkeit
:
Soluble in chloroform (1 mg/ml), and ethanol (250 µg/ml, cloudy suspension).
LAGERUNG:
:
Store at 4° C
Schmelztemperatur
:
>300° C
Sidepunkt
:
636.46° C at 760 mmHg (Predicted)
Dichte
:
1.47 g/cm3 (Predicted)
Brechungsindex
:
n20D 1.64 (Predicted)
IC50
:
Pin1/Par14 PPIase : IC50 = ~ 1.5 µM
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Transport
:
UN 3077, Class 9, Packing group III
PubChem CID
:
SMILES
:
CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O
SDS (MSDS) herunterladen
Analysenzertifikat
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