PP2A-A alpha / beta Antibody (H-2): sc-373738
- PP2A-Aα/β Antibody (H-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 574-601 at the C-terminus of PP2A-Aβ of human origin
- recommended for detection of PP2A-Aα and PP2A-Aβ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and porcine and canine
- See PP2A-Aα (6G3): sc-56954 for PP2A-Aα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PP2A-Aα/β Antibody (H-2) for WB applications. This reagent is now offered in a bundle with PP2A-Aα/β Antibody (H-2) (see ordering information below).
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PP2A-Aα/β Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects PP2A-Aα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-Aα/β is a crucial regulatory subunit of the protein phosphatase 2A (PP2A) complex, which plays a vital role in cellular signaling pathways by dephosphorylating serine and threonine residues on target proteins. This dephosphorylation is essential for regulating various cellular functions, including cell division, apoptosis, and maintaining cellular homeostasis. The PP2A complex is composed of a catalytic subunit and regulatory subunits, with PP2A-Aα/β being integral to its function, as PP2A-Aα/β helps determine substrate specificity and modulates the activity of the catalytic subunit. The interaction of PP2A-Aα/β with different regulatory subunits allows for a diverse range of cellular responses, making PP2A-Aα/β a key player in numerous signaling pathways. Understanding PP2A-Aα/β dynamics and interactions is critical for elucidating the mechanisms underlying various diseases, including cancer, where dysregulation of phosphatase activity can lead to uncontrolled cell growth.
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PP2A-A alpha / beta Antibody (H-2) References:
- Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. | Seshacharyulu, P., et al. 2013. Cancer Lett. 335: 9-18. PMID: 23454242
- A PP1-PP2A phosphatase relay controls mitotic progression. | Grallert, A., et al. 2015. Nature. 517: 94-98. PMID: 25487150
- PP2A in meiotic oocytes. | Yan, X. and Zhu, X. 2016. Cell Cycle. 15: 1950-1. PMID: 27210114
- Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1. | Kaur, A. and Westermarck, J. 2016. Biochem Soc Trans. 44: 1683-1693. PMID: 27913678
- Methylation-regulated decommissioning of multimeric PP2A complexes. | Wu, CG., et al. 2017. Nat Commun. 8: 2272. PMID: 29273778
- Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression. | Larouche, M., et al. 2021. J Cell Biol. 220: PMID: 33836042
- Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System. | Bryant, JP., et al. 2021. Cancers (Basel). 13: PMID: 34205611
- Renal AT2 Receptors Mediate Natriuresis via Protein Phosphatase PP2A. | Kemp, BA., et al. 2022. Circ Res. 130: 96-111. PMID: 34794320
- PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity. | Hasegawa, J., et al. 2022. Mol Biol Cell. 33: ar26. PMID: 35020443
- Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5. | Cao, R., et al. 2024. bioRxiv.. PMID: 37693604
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Aα/β Antibody (H-2) | sc-373738 | 200 µg/ml | $322.00 | |||
PP2A-Aα/β Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-540393 | 200 µg Ab; 10 µg BP | $361.00 | |||
PP2A-Aα/β (H-2) Neutralizing Peptide | sc-373738 P | 100 µg/0.5 ml | $69.00 |