PDE4C Antibody (4E5): sc-517011
- PDE4C Antibody (4E5) is a mouse monoclonal IgG3 κ PDE4C antibody provided at 100 µg/ml
- raised against amino acids 1-99 representing partial length PDE4C of human origin
- recommended for detection of PDE4C of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDE4C Antibody (4E5). This work is in progress.
PDE4C Antibody (4E5) is a mouse monoclonal IgG3 kappa light chain antibody that detects PDE4C protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PDE4C antibody (4E5) is available as the non-conjugated format. PDE4C protein is a member of the phosphodiesterase family, which plays a crucial role in the hydrolysis of cyclic adenosine monophosphate (cAMP) to 5′AMP, thereby regulating intracellular cAMP levels that are vital for various cellular processes, including signal transduction, inflammation, and neuronal signaling. PDE4 family is characterized by a unique upstream conserved region (UCR), and the human PDE4C gene, located on chromosome 19p13.1, produces several splice variants, including isoforms PDE4C1-7. Notably, the long isoforms of PDE4C contain both UCR1 and UCR2, which are essential for the dimerization of PDE4 isoforms, while the short isoforms possess only UCR2. This structural distinction influences the enzyme′s activity and regulatory mechanisms, making PDE4C a significant target for therapeutic interventions in conditions such as asthma, depression, and other inflammatory diseases.
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PDE4C Antibody (4E5) References:
- Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. | Sullivan, M., et al. 1999. Cell Signal. 11: 735-42. PMID: 10574328
- Cyclic nucleotide phosphodiesterases: relating structure and function. | Francis, SH., et al. 2001. Prog Nucleic Acid Res Mol Biol. 65: 1-52. PMID: 11008484
- Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs). | Richter, W. and Conti, M. 2002. J Biol Chem. 277: 40212-21. PMID: 12177055
- A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. | Bolger, G., et al. 1993. Mol Cell Biol. 13: 6558-71. PMID: 8413254
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDE4C Antibody (4E5) | sc-517011 | 100 µg/ml | $322.00 |