PD-149163 (CAS 169528-11-4)
Alternate Names:
N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine Ethyl Ester
CAS Number:
169528-11-4
Molecular Weight:
798.07
Molecular Formula:
C42H71N9O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD-149163 is a research compound that has interest in the field of neuroscience due to its ability to act as an agonist at the neurotensin receptor type 1 (NTSR1). Studies involving PD-149163 are focused on unraveling the role of neurotensin and its receptors in modulating neuronal signaling. PD-149163 is used in models to understand the effects of neurotensin receptor activation on cognitive processes, including learning and memory. Additionally, it aids in the investigation of neurotensin′s influence on dopaminergic systems, which has implications for understanding the pathophysiology of various neurological conditions.
PD-149163 (CAS 169528-11-4) References
- Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine. | Buhler, AV., et al. 2008. Pain. 135: 280-290. PMID: 17664042
- Effects of chronic infusion of neurotensin and a neurotensin NT1 selective analogue PD149163 on amphetamine-induced hyperlocomotion. | Norman, C., et al. 2008. J Psychopharmacol. 22: 300-7. PMID: 18208905
- The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle. | Shilling, PD. and Feifel, D. 2008. Pharmacol Biochem Behav. 90: 748-52. PMID: 18577396
- The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature. | Feifel, D., et al. 2010. Neuropharmacology. 58: 195-8. PMID: 19596358
- Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. | Guillemette, A., et al. 2012. Eur J Pain. 16: 473-84. PMID: 22396077
- Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats. | Prus, AJ., et al. 2014. Prog Neuropsychopharmacol Biol Psychiatry. 49: 78-84. PMID: 24275076
- Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats. | Steele, FF., et al. 2017. Brain Res. 1658: 31-35. PMID: 28089664
- Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain. | Liu, Q., et al. 2017. Brain Res. 1659: 148-155. PMID: 28130052
- Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. | Sharpe, AL., et al. 2017. PLoS One. 12: e0180710. PMID: 28686721
- Antinociceptive role of neurotensin receptor 1 in rats with chemotherapy-induced peripheral neuropathy. | Yin, M., et al. 2020. Korean J Pain. 33: 318-325. PMID: 32989196
- Systemically administered neurotensin receptor agonist produces antinociception through activation of spinally projecting serotonergic neurons in the rostral ventromedial medulla. | Li, Y., et al. 2021. Korean J Pain. 34: 58-65. PMID: 33380568
- Protective effect of neurotensin receptor-1 agonist PD 149163 against lipopolysaccharide-induced gut toxicity in mice. | Mishra, A. and Singh, KP. 2022. Drug Chem Toxicol. 45: 2399-2410. PMID: 34334065
- Neurotensin agonist PD 149163 modulates the neuroinflammation induced by bacterial endotoxin lipopolysaccharide in mice model. | Mishra, A. and Singh, KP. 2022. Immunopharmacol Immunotoxicol. 44: 216-226. PMID: 35166614
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD-149163, 10 mg | sc-477965 | 10 mg | $431.00 |