p38 alpha MAPK14 Antibody (D-5): sc-398305
- p38 alpha MAPK14 Antibody (D-5) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of p38α of mouse origin
- recommended for detection of p38α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- See p38 alpha/beta MAPK (A-12): sc-7972 for p38 alpha MAPK14 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p38 alpha MAPK14 Antibody (D-5) for WB applications. These reagents are now offered in bundles with p38 alpha MAPK14 Antibody (D-5) (see ordering information below).
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p38α Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect p38 alpha MAPK14 protein, also known as p38α, MAP kinase 14, or CSBP, across multiple species including mouse, rat, human, canine, bovine, and porcine. p38α monoclonal antibody (D-5) targets an epitope mapping between amino acids 2-31 at the N-terminus of mouse p38α, making it suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38 alpha MAPK14 protein is a critical member of the mitogen-activated protein kinase (MAPK) family, which plays a vital role in transmitting extracellular signals to the nucleus, thereby regulating various cellular responses. Located primarily in the cytoplasm, p38 alpha MAPK14 translocates to the nucleus upon activation, where p38 alpha MAPK14 phosphorylates transcription factors and other nuclear proteins, facilitating the expression of genes involved in inflammation, cell differentiation, apoptosis, and stress responses. This strategic localization allows p38 alpha MAPK14 to efficiently mediate signal transduction pathways that are essential for cellular adaptation to environmental changes and stress stimuli. By interacting with key proteins such as MKK3/6, ATF2, and MK2, p38 alpha MAPK14 orchestrates complex signaling networks that are fundamental to immune responses and the development of various diseases, including cancer and neurodegenerative disorders. Understanding the cellular localization and function of p38 alpha MAPK14 is crucial for elucidating its role in maintaining cellular homeostasis and responding to pathological conditions. anti-p38α antibody (D-5) is available in both non-conjugated and multiple conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing researchers with versatile tools to investigate the precise localization and functional dynamics of this kinase within different cellular compartments.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p38 alpha MAPK14 Antibody (D-5) References:
- The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research. | Menon, MB., et al. 2015. Autophagy. 11: 1425-7. PMID: 26061537
- The Stress Kinase p38α as a Target for Cancer Therapy. | Igea, A. and Nebreda, AR. 2015. Cancer Res. 75: 3997-4002. PMID: 26377941
- Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. | Zhang, X., et al. 2019. J Hepatol. 71: 163-174. PMID: 30914267
- P38α MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease. | Germann, UA. and Alam, JJ. 2020. Int J Mol Sci. 21: PMID: 32751991
- DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity. | Yang, L., et al. 2022. Food Chem Toxicol. 164: 113046. PMID: 35447293
- The kinase p38α functions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation. | Han, M., et al. 2022. Cell Mol Immunol. 19: 805-819. PMID: 35551270
- P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation. | Tang, Y., et al. 2022. Proc Natl Acad Sci U S A. 119: e2206000119. PMID: 35914132
- Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway. | González, L., et al. 2023. Nat Commun. 14: 3318. PMID: 37308482
- MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution. | Fortier, SM., et al. 2024. J Clin Invest. 134: PMID: 38512415
- Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase. | Kumar, S., et al. 1996. J Biol Chem. 271: 30864-9. PMID: 8940070
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p38 alpha MAPK14 Antibody (D-5) | sc-398305 | 200 µg/ml | $322.00 | |||
p38 alpha MAPK14 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-538415 | 200 µg Ab; 10 µg BP | $361.00 | |||
p38 alpha MAPK14 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-536026 | 200 µg Ab; 40 µg BP | $361.00 | |||
p38 alpha MAPK14 Antibody (D-5): m-IgG1 BP-HRP Bundle | sc-545693 | 200 µg Ab; 20 µg BP | $361.00 | |||
p38 alpha MAPK14 (D-5) Neutralizing Peptide | sc-398305 P | 100 µg/0.5 ml | $69.00 |