p-Stat1 Antibody (PSM1): sc-51700

p-Stat1 Antibody (PSM1) is a mouse monoclonal IgG1 antibody that detects Stat1 activated by phosphorylation at Ser 727 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Stat1 (PSM1) antibody is available in a non-conjugated form, allowing for versatile experimental use. Stat1 plays a crucial role in mediating cellular responses to various cytokines, particularly interferons, which are vital for the immune response and antiviral defense. Upon activation, Stat1 translocates to the nucleus where Stat1 regulates the expression of genes involved in immune function and inflammation. The phosphorylation of Stat1 at Ser 727 enhances transcriptional activity, allowing for a more robust response to cytokine signaling. This modification is essential for forming the ISGF3 transcription factor complex, which includes Stat1 and Stat2, and is critical for expressing interferon-stimulated genes. Understanding Stat1 activation dynamics and downstream effects is vital for elucidating immune regulation mechanisms and developing therapeutic strategies targeting immune-related diseases.

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p-Stat1 Antibody (PSM1) References:

1. Tuning up STAT1.  |  Sedwick, C. 2015. PLoS Biol. 13: e1002201. PMID: 26196960
2. STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential.  |  Chmielewski, S., et al. 2016. Int Rev Immunol. 35: 434-454. PMID: 26606328
3. STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.  |  Kang, YH., et al. 2019. Nat Commun. 10: 912. PMID: 30796216
4. STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism.  |  Kondo, S., et al. 2020. Biochem Biophys Res Commun. 523: 672-677. PMID: 31948748
5. STAT1 deficiency predisposes to spontaneous otitis media.  |  Bodmer, D., et al. 2020. PLoS One. 15: e0239952. PMID: 32991625
6. STAT1 mediates the PI3K/AKT pathway through promoting microRNA-18a in nasal polyps.  |  Jian, B. and Yin, P. 2022. Immunopharmacol Immunotoxicol. 44: 194-205. PMID: 35021946
7. STAT1 signaling protects self-reactive T cells from control by innate cells during neuroinflammation.  |  Arbelaez, CA., et al. 2022. JCI Insight. 7: PMID: 35587373
8. TGF-β-p-STAT1-LAIR2 axis has a 'self-rescue' role for exhausted CD8+ T cells in hepatocellular carcinoma.  |  Pan, B., et al. 2023. Cell Oncol (Dordr). 46: 1625-1644. PMID: 37223874
9. Prolonged STAT1 activation in neurons drives a pathological transcriptional response.  |  Clark, DN., et al. 2023. J Neuroimmunol. 382: 578168. PMID: 37556887
10. S1PR1 suppresses lung adenocarcinoma progression through p-STAT1/miR-30c-5 p/FOXA1 pathway.  |  Chai, Y., et al. 2024. J Exp Clin Cancer Res. 43: 304. PMID: 39551792

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Stat1 Antibody (PSM1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Stat1 Antibody (PSM1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Stat1 Antibody (PSM1) Specifications

Alternate Product Name: Stat1

Product Clone Name: PSM1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: Ser 727

Epitope Target: p-Stat1 p84/p91

Epitope Species: human

Product Reactivity/Detection: Stat1 activated by phosphorylation at Ser 727

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for p-Stat1 Antibody (PSM1): N/A

The preferred Stat1 antibody is Stat1 Antibody (C-136): sc-464.