ORC4 Antibody (D-8): sc-393985
- ORC4 Antibody (D-8) is a mouse monoclonal IgM κ ORC4 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 375-398 near the C-terminus of ORC4 of human origin
- recommended for detection of ORC4 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-393985 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ORC4 Antibody (D-8). This work is in progress.
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ORC4 Antibody (D-8) is a mouse monoclonal IgM antibody that detects ORC4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ORC4 antibody (D-8) is available as a non-conjugated monoclonal isotype antibody. ORC4 is a vital component of the origin recognition complex (ORC), which is essential for the initiation of DNA replication. ORC4 plays a critical role in forming pre-replication complexes necessary for accurate and timely genome replication. ORC4, along with other ORC subunits, binds to specific origins of replication, serving as a scaffold for assembling additional initiation factors. This interaction ensures DNA replication occurs at the right time during the cell cycle, particularly at the G1/S transition. Proper functioning of ORC4 is important not only for cell proliferation but also for maintaining genomic stability, as replication errors can lead to mutations and contribute to various diseases, including cancer. ORC4 expression remains consistent throughout the cell cycle, highlighting its importance in regulating DNA replication across different cell types.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ORC4 Antibody (D-8) | sc-393985 | 200 µg/ml | $322.00 | |||
ORC4 (D-8) Neutralizing Peptide | sc-393985 P | 100 µg/0.5 ml | $69.00 | |||
ORC4 Antibody (D-8) X | sc-393985 X | 200 µg/0.1 ml | $322.00 |