Molecular structure of Olomoucine, CAS Number: 101622-51-9
Olomoucine (CAS 101622-51-9)
See product citations (12)
Alternate Names:
2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine
Application:
Olomoucine is a potent and selective inhibitor of Cdc2 and ERK1
CAS Number:
101622-51-9
Purity:
≥98%
Molecular Weight:
298.34
Molecular Formula:
C15H18N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Olomoucine is a purine that acts as a competitive inhibitor of a variety of cell cycle regulating proteins with high specificity, which leads to the blockage of some cell cycle steps. The compound inhibits: Cdc2/cyclin B, Cdk2/cyclin A and Cdk2/cyclin E kinases, the brain Cdk5/p35 kinase and the ERK1/MAP-kinase. Olomoucine does not significantly inhibit Cdk4/cyclin D1 and Cdk6/cyclin D3 kinases. The compound can induce cell arrest at G1/S and the G2/M, due to its effect on Ckd2 and Cdcd2. Olomoucine also behaves as a competitive inhibitor for ATP and as a non-competitive inhibitor for histone H1 in terms of being Cdk substrates.
Olomoucine (CAS 101622-51-9) References
- Differential effects of 6-DMAP, olomoucine and roscovitine on Xenopus oocytes and eggs. | Flament, S., et al. 2000. Zygote. 8: 3-14. PMID: 10840869
- The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo. | Tripathi, BK., et al. 2008. Mol Vis. 14: 542-9. PMID: 18385789
- Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. | Fei, XF., et al. 2009. Brain Res. 1264: 85-97. PMID: 19368812
- The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors. | Korinkova, G., et al. 2010. Neoplasma. 57: 161-9. PMID: 20099981
- Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion. | Chen, L., et al. 2014. Neural Regen Res. 9: 1830-8. PMID: 25422646
- Down-regulation of BNIP3 by olomoucine, a CDK inhibitor, reduces LPS- and NO-induced cell death in BV2 microglial cells. | Tsou, YC., et al. 2016. Neurosci Lett. 628: 186-93. PMID: 27345388
- Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats. | Yew, WP., et al. 2021. J Neuroinflammation. 18: 168. PMID: 34332596
- Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions. | Glab, N., et al. 1994. FEBS Lett. 353: 207-11. PMID: 7523194
- Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. | Abraham, RT., et al. 1995. Biol Cell. 83: 105-20. PMID: 7549905
- Inhibition of cyclin-dependent kinases by purine analogues. | Veselý, J., et al. 1994. Eur J Biochem. 224: 771-86. PMID: 7925396
Inhibitor of:
1700018G05Rik, 4933404M19Rik, 4933411G11Rik, ALS2CR7, ANKRD20A1, ANKRD20A3, BEND6, Beta-NAP, BTG4, C12orf28, C12orf45, C12orf50_1700017N19Rik, C12orf63, C2orf30, C2orf37, C430003P19Rik, C430048L16Rik, C630004H02Rik, C6orf1, C8orf45, Cables2, CCDC77, CCNI2, CCNJL, CCRK, Cdc123, Cdc14, Cdc14a phosphatase, Cdc2, Cdc28, CDCrel-1, Cdk11, Cdk2, Cdk5, CINP, Cks2, Clb2, COASTER, Collapsin Response Mediator Protein (CRMP), CPAN, cyclin E2, cyclin F, cyclin I, cyclin J, cyclin M2, cyclin YL1, D14Ertd449e, Dbf4b, DEPDC1, DOC1, Dtl, E2F-6, E2F-8, eEF2K, ENSA, ERK 1, FAM111B, FAM127C, FAM160A1, FAM194A, FAM64A, FLJ32549, fzr, GAK, GEMC1, Gm355, Gm606, Gm75, GMD, GON4L, GPN3, Gtlf3b, HEXDC, IGHMBP2, INCA1, Inv, KBP, KIAA0317, KIAA0701, KIAA0753, KKIALRE, KPRP, LAGE-3, LIN-52, LIN37, LOC341346, LOC643862, MCEMP1, MIPU1, MPc3_CBX8, MPHOSPH8, Naglt1a, nArgBP2, NIF3L1 BP1, Nim1, NOL8, OTTMUSG00000016588, p21, P2P-R, Peregrin, PISSLRE, PITSLRE B, POGZ, PREI4, RBA-2, Repetin, RFC2, ROGDI, RWDD2A, RY1, SART-3, Ser/Thr Protein Kinase, SERTAD3, SERTAD4, SHPRH, SLBP, Speedy A, Speedy E3, SRRD, String, TCHHL1, TEX27, TFIIH p89, THEG, TLK2, TMEM194, TSGA10IP, V1RG1, Vmn2r42, Vmn2r7, Vmn2r78, WDR21, Wee 2, Xlr3a, ZFP260, ZHX3, ZNF2, and ZNF705A.Activator of:
C6orf114, Cables1, CCRK, CdcA4, Cdk10, Cdk11, CDK2AP1, CDKN2AIP, CEP72, Cig2, Clb1, Clik1, CPSF, CSAP, cyclin E2, cyclin G2, cyclin YL3, EG384244, FAM171A1, GBDR1, GBP6, KIAA1671, LOC441258, LOC643862, p39, PEG-3, PISSLRE, PITSLRE A, SBK1, SOLO, and Speedy A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Olomoucine, 5 mg | sc-3509 | 5 mg | $72.00 | |||
Olomoucine, 25 mg | sc-3509A | 25 mg | $274.00 |