Oct-6 Antibody (A-8): sc-376093

Oct-6 Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects Oct-6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oct-6, also known as SCIP or Tst-1, is a crucial transcription factor that plays a significant role in the development and differentiation of Schwann cells in the peripheral nervous system. Oct-6 (A-8) antibody targets a protein primarily expressed in late embryonic Schwann cells and continues to be present in nonmyelinating Schwann cells in adults. Oct-6 expression is particularly important during the myelination process, as anti-Oct-6 antibody (A-8) helps detect proteins essential for the timely differentiation of promyelin cells into myelinating cells, ensuring proper nerve function and signal transmission. Oct-6 (A-8) monoclonal antibody enables researchers to study how Oct-6 is involved in the downregulation of its own gene during myelination, a critical step for the maturation of Schwann cells. Notably, c-Myc can interact with the POU domain of Oct-6, leading to implications in myelin disease pathogenesis within the mammalian central nervous system. Oct-6 (A-8) monoclonal antibody serves as an invaluable tool for researchers studying the mechanisms of myelination and Schwann cell biology.

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Oct-6 Antibody (A-8) References:

1. Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.  |  Gong, S., et al. 2002. Exp Hematol. 30: 1162-9. PMID: 12384147
2. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.  |  Suzuki, N., et al. 1990. EMBO J. 9: 3723-32. PMID: 1976514
3. Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses.  |  Hofmann, E., et al. 2010. BMC Cell Biol. 11: 61. PMID: 20687925
4. Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding.  |  Jagalur, NB., et al. 2011. J Neurosci. 31: 8585-94. PMID: 21653862
5. Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects.  |  Li, G., et al. 2017. Stem Cell Reports. 8: 1270-1286. PMID: 28434941
6. The correlation between insulin and OCT-6 transcription factor in Schwann cells and sciatic nerve of diabetic rats.  |  Manu, MS., et al. 2018. Genes Dis. 5: 130-136. PMID: 30258942
7. The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress.  |  Fionda, C., et al. 2019. Cancers (Basel). 11: PMID: 31212703
8. Oct-6 transcriptional factor a possible biomarker for leprosy diagnosis.  |  Serrano-Coll, H., et al. 2021. Diagn Microbiol Infect Dis. 99: 115232. PMID: 33130505
9. OCT6 inhibits differentiation of porcine-induced pluripotent stem cells through MAPK and PI3K signaling regulation.  |  Yang, XC., et al. 2022. Zool Res. 43: 911-922. PMID: 36052561
10. The transcription factor OCT6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory network.  |  Waisman, A., et al. 2024. Sci Rep. 14: 10420. PMID: 38710730

The preferred Oct-6 antibody is Oct-6 Antibody (B-7): sc-376143.