Neuregulin-2 Antibody (H-8): sc-390646
- Neuregulin-2 Antibody (H-8) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 267-298 of Neuregulin-2 of human origin
- recommended for detection of Neuregulin-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Neuregulin-2 Antibody (H-8). This work is in progress.
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Neuregulin-2 Antibody (H-8) is a mouse monoclonal IgG2b antibody that detects Neuregulin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neuregulin-2 plays a crucial role in nervous system and heart development, influencing growth and differentiation of various cell types. Anti-Neuregulin-2 antibody (H-8) is particularly important for studying synaptic plasticity and neuronal signaling regulation, which are essential for cognitive functions and memory formation. Neuregulin-2 has been implicated in immune response modulation and may interact with specific proteins such as ErbB receptors, which are vital for cell communication and signaling pathways. Anti-Neuregulin-2 antibody (H-8) binding capabilities highlight Neuregulin-2′s significance in both normal physiological processes and potential pathological conditions, including cancer and neurodegenerative diseases. With versatile applications and critical role in cellular functions, Neuregulin-2 monoclonal antibody (H-8) serves as an invaluable tool for researchers studying cell signaling and development complexities.
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Neuregulin-2 Antibody (H-8) References:
- Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4. | Rimer, M., et al. 2004. Mol Cell Neurosci. 26: 271-81. PMID: 15207852
- NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3. | Nakano, N., et al. 2016. Neurosci Lett. 622: 88-94. PMID: 27113200
- Identification of Neuregulin-2 as a novel stress granule component. | Kim, JA., et al. 2016. BMB Rep. 49: 449-54. PMID: 27345716
- Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. | Yan, L., et al. 2018. Mol Psychiatry. 23: 1233-1243. PMID: 28322273
- NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release by ADAM10 [corrected]. | Vullhorst, D. and Buonanno, A. 2019. Mol Neurobiol. 56: 8345-8363. PMID: 31240601
- Correction to: NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release by ADAM10. | Vullhorst, D. and Buonanno, A. 2020. Mol Neurobiol. 57: 585. PMID: 31522381
- Proteolytic Processing of Neuregulin 2. | Czarnek, M. and Bereta, J. 2020. Mol Neurobiol. 57: 1799-1813. PMID: 31838721
- Neuregulin 2 (NRG2) is expressed in gliomas and promotes migration of human glioma cells. | Zhao, WJ., et al. 2021. Folia Neuropathol. 59: 189-197. PMID: 34284546
- [Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression via Akt signaling]. | Zhao, W. and Lin, J. 2021. Nan Fang Yi Ke Da Xue Xue Bao. 41: 1171-1176. PMID: 34549707
- Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. | Carraway, KL., et al. 1997. Nature. 387: 512-6. PMID: 9168115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neuregulin-2 Antibody (H-8) | sc-390646 | 200 µg/ml | $322.00 | |||
Neuregulin-2 (H-8) Neutralizing Peptide | sc-390646 P | 100 µg/0.5 ml | $69.00 |