Mucin 1/MUC1 Antibody (Vu-2G7): sc-69644
- Mucin 1/MUC1 Antibody (Vu-2G7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against a synthetic 60-mer Mucin 1 triple tandem repeat peptide with N-acetyl-galactosamine (GalNAc) O-linked to the threonine in the PDTR region of each repeat (3M GalNAc)
- recommended for detection of glycosylated PDTR motif of the Mucin 1 tandem repeat of human origin by WB, IP, IF and IHC(P); not recommended for detection of non-glycosylated Mucin 1
- See Mucin 1/MUC1 (VU4H5): sc-7313 for Mucin 1/MUC1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Mucin 1/MUC1 Antibody (Vu-2G7) for WB and IHC(P) applications. These reagents are now offered in bundles with Mucin 1/MUC1 Antibody (Vu-2G7) (see ordering information below).
Mucin 1 Antibody (Vu-2G7) is a mouse monoclonal IgG1 antibody that detects Mucin 1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Mucin 1 is a type I membrane protein that plays a crucial role in cell signaling and protection of epithelial cells, particularly in the context of cancer. Mucin 1′s aberrant expression in epithelial tumors, including breast carcinomas, highlights its importance as a potential biomarker for cancer diagnosis and prognosis. Mucin 1′s structure, characterized by a variable number of tandem repeats, contributes to its ability to form a protective mucosal barrier and interact with various signaling molecules, which is vital for maintaining cellular homeostasis and responding to environmental stressors. Mucin 1′s unique glycosylation patterns also influence interactions with other proteins, making Mucin 1 a key player in tumor progression and metastasis. Anti-Mucin 1 antibody (Vu-2G7) is an essential tool for researchers investigating cancer biology and therapeutic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mucin 1/MUC1 Antibody (Vu-2G7) References:
- Mucin 1-specific B cell immune responses and their impact on overall survival in breast cancer patients. | Fremd, C., et al. 2016. Oncoimmunology. 5: e1057387. PMID: 26942066
- Critical roles of mucin-1 in sensitivity of lung cancer cells to tumor necrosis factor-alpha and dexamethasone. | Xu, M. and Wang, X. 2017. Cell Biol Toxicol. 33: 361-371. PMID: 28470556
- Sputum mucin 1 is increased during the acute phase of chronic obstructive pulmonary disease exacerbation. | Zheng, Z., et al. 2017. J Thorac Dis. 9: 1873-1882. PMID: 28839985
- Inverse association of rab31 and mucin-1 (CA15-3) antigen levels in estrogen receptor-positive (ER+) breast cancer tissues with clinicopathological parameters and patients' prognosis. | Kotzsch, M., et al. 2017. Am J Cancer Res. 7: 1959-1970. PMID: 28979817
- Clinical value of a diagnostic score for colon cancer based on serum CEA, CA19-9, cytokeratin-1 and mucin-1. | Attallah, AM., et al. 2018. Br J Biomed Sci. 75: 122-127. PMID: 29734875
- Homogeneous electrochemical aptasensor for mucin 1 detection based on exonuclease I-assisted target recycling amplification strategy. | Lin, C., et al. 2018. Biosens Bioelectron. 117: 474-479. PMID: 29982116
- Clinical associations of mucin 1 in human lung cancer and precancerous lesions. | Saltos, A., et al. 2018. Oncotarget. 9: 35666-35675. PMID: 30479696
- Liposomal Antitumor Vaccines Targeting Mucin 1 Elicit a Lipid-Dependent Immunodominant Response. | Du, JJ., et al. 2019. Chem Asian J. 14: 2116-2121. PMID: 31042017
- Cancer Antigen 15-3/Mucin 1 Levels in CCTG MA.32: A Breast Cancer Randomized Trial of Metformin vs Placebo. | Goodwin, PJ., et al. 2021. JNCI Cancer Spectr. 5: PMID: 34485814
- Evaluation of mucin-1, nuclear factor κB, and hemoglobin A1c levels in obese and non-obese individuals. | Fadıloğlu, M., et al. 2024. Rev Assoc Med Bras (1992). 70: e20231214. PMID: 38716942
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 1/MUC1 Antibody (Vu-2G7) | sc-69644 | 200 µg/ml | $322.00 | |||
Mucin 1/MUC1 Antibody (Vu-2G7): m-IgG Fc BP-HRP Bundle | sc-539211 | 200 µg Ab; 10 µg BP | $361.00 | |||
Mucin 1/MUC1 Antibody (Vu-2G7): m-IgG1 BP-HRP Bundle | sc-541329 | 200 µg Ab; 20 µg BP | $361.00 |