Mucin 1/MUC1 Antibody (BC-2): sc-52347

Mucin 1 Antibody (BC-2) is a mouse monoclonal IgG1 antibody that detects Mucin 1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Mucin 1 plays a crucial role in cell signaling and adhesion, acting as a protective barrier on epithelial surfaces and contributing to the maintenance of tissue integrity. Mucin 1 (BC-2) antibody is particularly significant in studying epithelial tumors, including breast carcinomas, where Mucin 1 can influence tumor progression and metastasis. Mucin 1 is primarily localized to the apical surface of epithelial cells, where Mucin 1 forms a gel-like layer that traps pathogens and particulates, thereby playing a vital role in the immune response. Mucin 1′s structure, characterized by a large extracellular domain rich in glycosylation, not only enhances protective functions but also facilitates interactions with various signaling molecules, making anti-Mucin 1 antibody (BC-2) a key tool in both normal physiology and disease states research.

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Mucin 1/MUC1 Antibody (BC-2) References:

1. Mucin 1, Thomsen-Friedenreich expression and galectin-1 binding in endometrioid adenocarcinoma: an immunohistochemical analysis.  |  Mylonas, I., et al. 2007. Anticancer Res. 27: 1975-80. PMID: 17649808
2. Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localization.  |  Andrulis, M., et al. 2014. Histopathology. 64: 799-806. PMID: 24251368
3. Mucin 1 and cytokines mRNA in endometrium of dairy cows with postpartum uterine disease or repeat breeding.  |  Kasimanickam, R., et al. 2014. Theriogenology. 81: 952-958.e2. PMID: 24576715
4. Electrochemical aptasensor for mucin 1 based on dual signal amplification of poly(o-phenylenediamine) carrier and functionalized carbon nanotubes tracing tag.  |  Chen, X., et al. 2015. Biosens Bioelectron. 64: 485-92. PMID: 25290645
5. Mucin 1 and poly I:C activates dendritic cells and effectively eradicates pituitary tumors as a prophylactic vaccine.  |  Sui, D., et al. 2016. Mol Med Rep. 13: 3675-83. PMID: 26935338
6. Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients.  |  Nie, M., et al. 2016. J Am Soc Nephrol. 27: 3447-3458. PMID: 27036738
7. Regulation of Mucin 1 and multidrug resistance protein 1 by honokiol enhances the efficacy of doxorubicin-mediated growth suppression in mammary carcinoma cells.  |  Thulasiraman, P. and Johnson, AB. 2016. Int J Oncol. 49: 479-86. PMID: 27221150
8. Expression of mucin-1 in oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study.  |  Thakur, A., et al. 2018. J Oral Maxillofac Pathol. 22: 210-215. PMID: 30158774
9. Mucin-1 expression and localization in epithelial cells shows characteristic and distinct patterns in inflammatory bowel diseases and colorectal cancer.  |  Khemiri, M., et al. 2019. Int J Clin Exp Pathol. 12: 1731-1737. PMID: 31933991
10. Combined Expression of HGFR with Her2/neu, EGFR, IGF1R, Mucin-1 and Integrin α2β1 Is Associated with Aggressive Epithelial Ovarian Cancer.  |  Czogalla, B., et al. 2022. Biomedicines. 10: PMID: 36359213

The preferred Mucin 1/MUC1 antibody is Mucin 1/MUC1 Antibody (VU4H5): sc-7313.