MIS Antibody (B-9): sc-365643

MIS Antibody (B-9) is a mouse monoclonal IgG2a antibody that detects Mullerian inhibiting substance (MIS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MIS antibody (B-9) plays a crucial role in the regulation of sexual differentiation during embryonic development, as MIS is produced by Sertoli cells in the fetal testis and is essential for male offspring development. MIS, along with testosterone, leads to the regression of the Mullerian ducts, which are precursors to female reproductive structures, while promoting the differentiation of the Wolffian ducts, which develop into male reproductive organs. This process is vital for proper sexual differentiation, and any defects in MIS can result in conditions such as persistent Mullerian duct syndrome type I (PMDS-1), a form of male pseudohermaphroditism characterized by the failure of Mullerian duct regression. MIS (B-9) antibody′s ability to detect MIS protein involved in inhibiting tumor growth derived from Mullerian duct tissues further underscores its importance in both developmental biology and potential therapeutic applications. Anti-MIS antibody (B-9) serves as an invaluable tool for researchers studying the intricate mechanisms of sexual differentiation and related disorders.

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MIS Antibody (B-9) References:

1. Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications.  |  Teixeira, J., et al. 2001. Endocr Rev. 22: 657-74. PMID: 11588147
2. Enhanced purification and production of Müllerian inhibiting substance for therapeutic applications.  |  Donahoe, PK., et al. 2003. Mol Cell Endocrinol. 211: 37-42. PMID: 14656474
3. Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development.  |  Whitman, GF. and Pantazis, CG. 1991. Am J Obstet Gynecol. 165: 1881-6. PMID: 1750488
4. Mullerian inhibiting substance: a fetal hormone with surgical implications.  |  Hutson, JM., et al. 1985. Aust N Z J Surg. 55: 599-605. PMID: 2870703
5. Quantification of Müllerian Inhibiting Substance/Anti-Müllerian Hormone polypeptide by isotope dilution mass spectrometry.  |  Whiting, G., et al. 2018. Anal Biochem. 560: 50-55. PMID: 29742446
6. Expression of Müllerian-Inhibiting Substance/Anti-Müllerian Hormone Type II Receptor in the Human Theca Cells.  |  Cheon, KY., et al. 2018. J Clin Endocrinol Metab. 103: 3376-3385. PMID: 29947765
7. Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome.  |  Hsu, JY., et al. 2018. J Clin Endocrinol Metab. 103: 4187-4196. PMID: 30239805
8. Functional profiles of Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) in primarily cultured endometrial cancer cells.  |  Kim, SI., et al. 2021. J Cancer. 12: 6289-6300. PMID: 34539902
9. Breast cancer risk coordinators: Artificial intelligence-based density measurement and Mullerian-inhibiting substance.  |  Pedük, Ş., et al. 2023. Ir J Med Sci. 192: 1601-1606. PMID: 36229588
10. New insights into mullerian inhibiting substance and its mechanism of action.  |  Lane, AH. and Donahoe, PK. 1998. J Endocrinol. 158: 1-6. PMID: 9713320

The preferred MIS antibody is MIS Antibody (B-11): sc-166752.