MIF Antibody (11): sc-130329

MIF Antibody (11) is a mouse monoclonal IgG2a antibody that detects macrophage migration inhibitory factor (MIF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MIF is a secreted, homotrimeric pro-inflammatory cytokine that plays a crucial role in modulating macrophage and T cell functions, making anti-MIF antibody (11) an essential tool for studying host immune response to infection. MIF is primarily produced by the pituitary gland and is expressed in various immune cells, including monocytes and macrophages, as well as in differentiating cells in the eye lens and brain. Notably, MIF is found at sites of inflammation, indicating significant involvement in regulating macrophage activity during host defense. Elevated levels of MIF have been associated with severe sepsis and septic shock, where MIF enhances the production of other inflammatory cytokines such as tumor necrosis factor α (TNFα), interleukin-1 (IL-1), and interferon-γ (IFN-γ). Furthermore, MIF′s ability to counteract glucocorticoid-mediated inhibition of immune-cell activation underscores MIF′s role in promoting systemic inflammatory responses. MIF monoclonal antibody (11) serves as an invaluable tool for researchers investigating the complex mechanisms of inflammation and immune regulation, providing insights into potential therapeutic targets for inflammatory diseases.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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MIF Antibody (11) References:

1. Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth.  |  Nishihira, J. 2000. J Interferon Cytokine Res. 20: 751-62. PMID: 11032394
2. The vascular biology of macrophage migration inhibitory factor (MIF). Expression and effects in inflammation, atherogenesis and angiogenesis.  |  Asare, Y., et al. 2013. Thromb Haemost. 109: 391-8. PMID: 23329140
3. Invariant Chain Complexes and Clusters as Platforms for MIF Signaling.  |  Lindner, R. 2017. Cells. 6: PMID: 28208600
4. Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.  |  Schmitz, C., et al. 2018. FASEB J. 32: 4428-4443. PMID: 29543531
5. MIF promotes perineural invasion through EMT in salivary adenoid cystic carcinoma.  |  Zhang, M., et al. 2019. Mol Carcinog. 58: 898-912. PMID: 30667094
6. MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma.  |  Qin, L., et al. 2021. Oncol Lett. 22: 549. PMID: 34093770
7. Host cell-type and pathogen-specific immunomodulatory functions of macrophage migration inhibitory factor (MIF) in infectious keratitis.  |  Ghosh, S., et al. 2023. Exp Eye Res. 236: 109669. PMID: 37774962
8. Macrophage Migration Inhibitory Factor (MIF) is a Key Player in Dry Eye Disease.  |  Rivera, LA., et al. 2024. Ocul Immunol Inflamm. 32: 1707-1721. PMID: 38127798
9. A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus.  |  Li, J., et al. 2024. J Biol Chem. 300: 107443. PMID: 38838773
10. Macrophage migration inhibitory factor (MIF) in CNS diseases: Functional regulation and potential therapeutic indication.  |  Zhang, Y., et al. 2024. Fundam Res. 4: 1375-1388. PMID: 39734533

The preferred MIF antibody is MIF Antibody (D-2): sc-271631.