MAP-2 Antibody (B-8): sc-74420
- MAP-2 Antibody (B-8) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of MAP-2 of human origin
- recommended for detection of MAP-2 of human origin by WB, IP, IF, IHC(P) and ELISA
- See MAP-2 (A-4): sc-74421 for MAP-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MAP-2 Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with MAP-2 Antibody (B-8) (see ordering information below).
MAP-2 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects MAP-2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MAP-2 is a crucial microtubule-associated protein that plays a significant role in stabilizing microtubules and facilitating their assembly, which is essential for maintaining the structural integrity of neurons. Anti-MAP-2 antibody (B-8) recognizes protein predominantly located in the dendrites of neurons, where MAP-2 contributes to the organization of the cytoskeleton and supports the transport of organelles and signaling molecules. The proper localization and function of MAP-2 are vital for neuronal development and plasticity, as disruptions in MAP-2 expression or function can lead to neurodegenerative diseases and cognitive impairments. MAP-2 monoclonal antibody (B-8) provides reliable detection and analysis of MAP-2, enabling researchers to explore MAP-2′s role in cellular processes and implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAP-2 Antibody (B-8) References:
- A study of a dendritic marker, microtubule-associated protein 2 (MAP-2), in rats neonatally treated neurosteroids, pregnenolone and dehydroepiandrosterone (DHEA). | Iwata, M., et al. 2005. Neurosci Lett. 386: 145-9. PMID: 16002213
- Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor. | Atalay, B., et al. 2007. Br J Neurosurg. 21: 281-7. PMID: 17612919
- Age-related decreases in SYN levels associated with increases in MAP-2, apoE, and GFAP levels in the rhesus macaque prefrontal cortex and hippocampus. | Haley, GE., et al. 2010. Age (Dordr). 32: 283-96. PMID: 20640549
- Association of acetylated microtubules, vimentin intermediate filaments, and MAP 2 during early neural differentiation in EC cell culture. | Falconer, MM., et al. 1989. Biochem Cell Biol. 67: 537-44. PMID: 2679799
- [Effect of acupuncture serum on expression of microtubule associated protein-2 and nerve growth associated protein-43 in Mg2+-free-cultured hippocampal neurons of neonatal rats]. | Zhang, H., et al. 2021. Zhen Ci Yan Jiu. 46: 1029-35. PMID: 34970880
- The pattern of MAP-2 binding on microtubules: visual enhancement of MAP attachment sites by antibody labeling and electron microscopy. | Gottlieb, RA. and Murphy, DB. 1983. J Ultrastruct Res. 85: 175-85. PMID: 6674502
- Electron microscopy of MAP 2 (microtubule-associated protein 2). | Voter, WA. and Erickson, HP. 1982. J Ultrastruct Res. 80: 374-82. PMID: 7131650
- Localization of specific epitopes on human microtubule-associated protein 2. | Kalcheva, N., et al. 1994. J Neurochem. 63: 2336-41. PMID: 7525876
- Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). | Albala, JS., et al. 1994. Gene. 149: 395-6. PMID: 7959031
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAP-2 Antibody (B-8) | sc-74420 | 200 µg/ml | $322.00 | |||
MAP-2 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-539516 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAP-2 Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-541537 | 200 µg Ab; 20 µg BP | $361.00 |