MAP-2 Antibody (AA6): sc-80013

MAP-2 Antibody (AA6) is a mouse monoclonal IgG2a antibody that detects microtubule-associated protein 2 (MAP-2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MAP-2 plays a crucial role in the stabilization and assembly of microtubules, which are essential components of the cytoskeletal network that provide structural support and shape to cells. MAP-2 (AA6) antibody targets proteins primarily located in neuronal cell bodies and dendrites, where MAP-2 contributes to the organization of the microtubule network, facilitating intracellular transport and maintaining the integrity of neuronal architecture. The proper functioning of MAP-2 is vital for neuronal development and plasticity, as MAP-2 influences the growth and branching of dendrites, which are critical for synaptic connectivity and communication between neurons. Dysregulation of MAP-2 has been associated with various neurodegenerative diseases, making MAP-2 an important target for research in understanding neuronal health and disease mechanisms. Anti-MAP-2 antibody (AA6) is an invaluable tool for researchers studying the dynamics of microtubules and their associated proteins in various biological contexts.

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MAP-2 Antibody (AA6) References:

1. Immunocytochemical expression of microtubule-associated protein-2 (MAP-2) in small cell lung cancer cell lines with neuronal-like processes.  |  Tanaka, K. and Terasaki, T. 2002. Jpn J Cancer Res. 93: 699-705. PMID: 12079519
2. Dietary aluminum selectively decreases MAP-2 in brains of developing and adult rats.  |  Johnson, GV., et al. 1992. Neurotoxicology. 13: 463-74. PMID: 1331920
3. The susceptibility of MAP-2 to proteolytic degradation increases when bound to tubulin.  |  Grau, E., et al. 1992. Neurochem Res. 17: 967-71. PMID: 1508306
4. Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment.  |  Liu, HX., et al. 2005. Brain Res Mol Brain Res. 139: 169-77. PMID: 15964096
5. Motor Skill Training Promotes Sensorimotor Recovery and Increases Microtubule-Associated Protein-2 (MAP-2) Immunoreactivity in the Motor Cortex after Intracerebral Hemorrhage in the Rat.  |  Santos, MV., et al. 2013. ISRN Neurol. 2013: 159184. PMID: 23956876
6. Anti-200 kDa neurofilament antibody cross-reacts with microtubule-associated protein-2 (MAP-2).  |  Allende, ML., et al. 1989. J Neurosci Res. 22: 130-3. PMID: 2468783
7. Expression of MAP 2 by haemangioblastomas: an immunohistochemical study with implications for diagnosis.  |  Malafronte, PJ., et al. 2014. Pathology. 46: 450-1. PMID: 24977729
8. Antibodies to microtubule-associated protein-2 in the cerebrospinal fluid are a useful diagnostic biomarker for neuropsychiatric systemic lupus erythematosus.  |  Yamada, Y., et al. 2016. Mod Rheumatol. 26: 562-8. PMID: 26667376
9. Ammonium injection induces an N-methyl-D-aspartate receptor-mediated proteolysis of the microtubule-associated protein MAP-2.  |  Felipo, V., et al. 1993. J Neurochem. 60: 1626-30. PMID: 8473887
10. Disruption of MAP-2 immunostaining in rat hippocampus after traumatic brain injury.  |  Folkerts, MM., et al. 1998. J Neurotrauma. 15: 349-63. PMID: 9605349

The preferred MAP-2 antibody is MAP-2 Antibody (A-4): sc-74421.