LRRTM1 Antibody (A-2): sc-390919

LRRTM1 Antibody (A-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects LRRTM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-LRRTM1 antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The leucine-rich repeat transmembrane neuronal 1 (LRRTM1) protein is a 522 amino acid single-pass type I membrane protein that predominantly localizes to the endoplasmic reticulum and features ten leucine-rich repeats, which are critical for structural integrity and function. These leucine-rich repeats form a hydrophobic α/β horseshoe fold, allowing LRRTM1 to engage in essential interactions that influence neuronal differentiation and connectivity. LRRTM1 is primarily expressed in forebrain tissue, where LRRTM1 plays a significant role in the development of forebrain structures by facilitating axon trafficking. Notably, human LRRTM1 shares 96% amino acid identity with mouse LRRTM1, indicating a highly conserved function across species. Defects in the gene encoding LRRTM1 have been implicated in the pathogenesis of several neurodevelopmental disorders, underscoring LRRTM1′s critical role in brain development and function.

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LRRTM1 Antibody (A-2) References:

1. The leucine-rich repeat as a protein recognition motif.  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
2. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system.  |  Laurén, J., et al. 2003. Genomics. 81: 411-21. PMID: 12676565
3. Structural principles of leucine-rich repeat (LRR) proteins.  |  Enkhbayar, P., et al. 2004. Proteins. 54: 394-403. PMID: 14747988
4. Leucine-rich repeats in host-pathogen interactions.  |  Kedzierski, Ł., et al. 2004. Arch Immunol Ther Exp (Warsz). 52: 104-12. PMID: 15179324
5. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases.  |  Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
6. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.  |  Francks, C., et al. 2007. Mol Psychiatry. 12: 1129-39, 1057. PMID: 17667961
7. LRRTM1 underlies synaptic convergence in visual thalamus.  |  Monavarfeshani, A., et al. 2018. Elife. 7: PMID: 29424692
8. Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus.  |  Karimi, B., et al. 2021. Mol Psychiatry. 26: 6912-6925. PMID: 33981006
9. Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.  |  Dhume, SH., et al. 2022. Elife. 11: PMID: 35662394
10. Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.  |  de Arce, KP., et al. 2023. Nat Commun. 14: 459. PMID: 36709330
11. Proteins with leucine-rich repeats.  |  Kobe, B. and Deisenhofer, J. 1995. Curr Opin Struct Biol. 5: 409-16. PMID: 7583641
12. The leucine-rich repeat: a versatile binding motif.  |  Kobe, B. and Deisenhofer, J. 1994. Trends Biochem Sci. 19: 415-21. PMID: 7817399

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRRTM1 Antibody (A-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LRRTM1 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRRTM1 Antibody (A-2) Specifications

Alternate Product Name: LRRTM1

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 347-446

Epitope Target: LRRTM1

Epitope Species: human

Product Reactivity/Detection: LRRTM1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LRRTM1 Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin