LDH-C Antibody (F-1): sc-377305
- LDH-C Antibody (F-1) is a mouse monoclonal IgG1 κ LDH-C antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 103-141 within an internal region of LDH-C of rat origin
- LDH-C Antibody (F-1) is recommended for detection of LDH-C of mouse and rat origin by WB, IP, IF and ELISA
- Anti-LDH-C Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for LDH-C Antibody (F-1) for WB applications. This reagent is now offered in a bundle with LDH-C Antibody (F-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
LDH-C Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects LDH-C protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LDH-C (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The lactate dehydrogenase family, which includes LDH-C, plays a crucial role in cellular metabolism by catalyzing the conversion of L-lactate and NAD to pyruvate and NADH, marking the final step of anaerobic glycolysis. Notably, LDH-C is uniquely expressed in testis and sperm, distinguishing LDH-C from LDH-A and LDH-B, which are predominantly found in muscle and heart tissues, respectively. This specific localization underscores LDH-C′s importance in male fertility and germ cell tumor diagnostics, making LDH-C a powerful biomarker in reproductive health studies. The genes encoding human LDH-A and LDH-C are located on chromosome 11, while human LDH-B gene is situated on chromosome 12, with deficiencies in LDH-A gene being associated with exertional myoglobinuria.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LDH-C Antibody (F-1) References:
- [The role of tumor markers in the treatment of germ cell tumor]. | Niwakawa, M. and Tobisu, K. 2001. Gan To Kagaku Ryoho. 28: 1159-65. PMID: 11525037
- Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli. | LeVan, KM. and Goldberg, E. 1991. Biochem J. 273 (Pt 3): 587-92. PMID: 1996957
- Locus determining the human sperm-specific lactate dehydrogenase, LDHC, is syntenic with LDHA. | Edwards, YH., et al. 1987. Dev Genet. 8: 219-32. PMID: 2844458
- Lactate dehydrogenase M-subunit deficiencies: clinical features, metabolic background, and genetic heterogeneities. | Kanno, T. and Maekawa, M. 1995. Muscle Nerve Suppl. 3: S54-60. PMID: 7603529
- Methods for the separation of lactate dehydrogenases and clinical significance of the enzyme. | Kopperschläger, G. and Kirchberger, J. 1996. J Chromatogr B Biomed Appl. 684: 25-49. PMID: 8906464
- Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. | Auerbach, G., et al. 1998. Structure. 6: 769-81. PMID: 9655830
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LDH-C Antibody (F-1) | sc-377305 | 200 µg/ml | $322.00 | |||
LDH-C Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-523274 | 200 µg Ab, 40 µg BP | $361.00 | |||
LDH-C Antibody (F-1) AC | sc-377305 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LDH-C Antibody (F-1) HRP | sc-377305 HRP | 200 µg/ml | $322.00 | |||
LDH-C Antibody (F-1) FITC | sc-377305 FITC | 200 µg/ml | $336.00 | |||
LDH-C Antibody (F-1) PE | sc-377305 PE | 200 µg/ml | $349.00 | |||
LDH-C Antibody (F-1) Alexa Fluor® 488 | sc-377305 AF488 | 200 µg/ml | $364.00 | |||
LDH-C Antibody (F-1) Alexa Fluor® 546 | sc-377305 AF546 | 200 µg/ml | $364.00 | |||
LDH-C Antibody (F-1) Alexa Fluor® 594 | sc-377305 AF594 | 200 µg/ml | $364.00 | |||
LDH-C Antibody (F-1) Alexa Fluor® 647 | sc-377305 AF647 | 200 µg/ml | $364.00 | |||
LDH-C Antibody (F-1) Alexa Fluor® 680 | sc-377305 AF680 | 200 µg/ml | $364.00 | |||
LDH-C Antibody (F-1) Alexa Fluor® 790 | sc-377305 AF790 | 200 µg/ml | $364.00 | |||
LDH-C (F-1) Neutralizing Peptide | sc-377305 P | 100 µg/0.5 ml | $69.00 |