Molecular structure of Latrunculin B, CAS Number: 76343-94-7
Latrunculin B (CAS 76343-94-7)
See product citations (29)
Alternate Names:
LAT-B; NSC 339663
Application:
Latrunculin B is an actin polymerization inhibitor
CAS Number:
76343-94-7
Purity:
≥96%
Molecular Weight:
395.51
Molecular Formula:
C20H29NO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Latrunculin B is a structurally unique marine toxin. It inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. This inhibition is done by sequestering G-actin and preventing F-actin assembly 10 to 100-fold more potent than cytochalasins.
Latrunculin B (CAS 76343-94-7) References
- Effect of latrunculin-B on outflow facility in monkeys. | Peterson, JA., et al. 2000. Exp Eye Res. 70: 307-13. PMID: 10712817
- Effects of cytochalasin D and latrunculin B on mechanical properties of cells. | Wakatsuki, T., et al. 2001. J Cell Sci. 114: 1025-36. PMID: 11181185
- Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B. | Hoye, TR., et al. 2002. J Am Chem Soc. 124: 7405-10. PMID: 12071749
- The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP. | Cha, B., et al. 2004. J Cell Sci. 117: 3353-65. PMID: 15226406
- Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity. | Kudrimoti, S., et al. 2009. Bioorg Med Chem. 17: 7517-22. PMID: 19800245
- AtFH8 is involved in root development under effect of low-dose latrunculin B in dividing cells. | Xue, XH., et al. 2011. Mol Plant. 4: 264-78. PMID: 21307369
- Inhibition of actin polymerisation by low concentration Latrunculin B affects endocytosis and alters exocytosis in shank and tip of tobacco pollen tubes. | Moscatelli, A., et al. 2012. Plant Biol (Stuttg). 14: 770-82. PMID: 22288466
- Effects of latrunculin B on the actin cytoskeleton and hyphal growth in Phytophthora infestans. | Ketelaar, T., et al. 2012. Fungal Genet Biol. 49: 1014-22. PMID: 23036581
- Chloroplast and oxygen evolution changes in Symbiodinium sp. as a response to latrunculin and butanedione monoxime treatments under various light conditions. | Villanueva, MA., et al. 2015. Photosynth Res. 124: 305-13. PMID: 25904178
- Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. | Lu, YY., et al. 2016. Clin Sci (Lond). 130: 721-32. PMID: 26839418
- Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D. | Spector, I., et al. 1989. Cell Motil Cytoskeleton. 13: 127-44. PMID: 2776221
- Latrunculin A is a potent inhibitor of phagocytosis by macrophages. | de Oliveira, CA. and Mantovani, B. 1988. Life Sci. 43: 1825-30. PMID: 3200109
- Inhibition of actin polymerization by latrunculin A. | Coué, M., et al. 1987. FEBS Lett. 213: 316-8. PMID: 3556584
- Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice. | Schatten, G., et al. 1986. Exp Cell Res. 166: 191-208. PMID: 3743654
- Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. | Spector, I., et al. 1983. Science. 219: 493-5. PMID: 6681676
Inhibitor of:
α-actinin-1, α-actinin-4, ζ2-COP, 2410002O22Rik, A330021E22Rik, Actin, AP1S3, ARHGAP12, ARL11, ARL14EPL, BC006779, Calponin 3, COG4, COPZ2, DENND5B, Desmuslin, Expansin, Flightless I, Gm732, Gm949, GOLGA6L1, GOLGB1, golgin 160, GS28, MYBPH, Myosin XVI, NEEP21, NEURL1B, PACSIN3, POR1, Rab 3 GAP p150, Rab 40AL, Rab 5B, Rab11-FIP4, RGNEF, Sar1, SEC22A, Septin 12, SMAP1, SNX5, SYP, TBC1D19, TFG, TGN38B, TRAPPC5, Villin, Vmn2r1, Vmn2r3, VPS45, WDR26, YIF1A, YIF1B, and YJEFN3.Activator of:
β′-COP, ARHGAP15, ARHGAP30, D6Wsu116e, EG433102, FAM18A, FAM39E, FHOD3, GMF-β, MRCKα, Myosin Va, Myosin Vb, NEURL1B, palladin, Rab 3A, Rab 5A, SEMA6B, Swiprosin-2, TAZ, and VgI-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Latrunculin B, 1 mg | sc-203318 | 1 mg | $240.00 |