Molecular structure of KN-62, CAS Number: 127191-97-3
KN-62 (CAS 127191-97-3)
See product citations (20)
Alternate Names:
1-[N,O-Bis(5-Isoquinolinesulfonyl)-N-Methyltyrosyl]-4-Phenylpiperazine
Application:
KN-62 is a potent and selective inhibitor of CaMKII
CAS Number:
127191-97-3
Purity:
≥95%
Molecular Weight:
721.84
Molecular Formula:
C38H35N5O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII Ki=0.9 muM) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 muM of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). KN-62 is a cell-permeable compound that selectively inhibits CaM kinase II, an enzyme involved in calcium signaling (IC50 = 500 nM).
KN-62 (CAS 127191-97-3) References
- KN-62 provides neuroprotection against glutamate-induced excitotoxicity in neurons. | Gao, C. and Zhang, GY. 1999. Zhongguo Yao Li Xue Bao. 20: 991-4. PMID: 11270980
- Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. | Mühl, H., et al. 2003. Eur J Pharmacol. 482: 325-8. PMID: 14660039
- KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells. | Hübner, K. and Phi-van, L. 2004. Biochem Biophys Res Commun. 319: 405-9. PMID: 15178421
- KN-62 analogues as potent differentiating agents of HL-60 cells. | Schuler, AD., et al. 2007. Leuk Res. 31: 683-9. PMID: 16963120
- CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1α in Hepatoma Cells. | Lee, KH. 2010. Korean J Physiol Pharmacol. 14: 331-6. PMID: 21165333
- KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. | Tokumitsu, H., et al. 1990. J Biol Chem. 265: 4315-20. PMID: 2155222
- Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells. | Obata, NH., et al. 1995. Biochem Biophys Res Commun. 215: 566-71. PMID: 7487993
- KN-62, an inhibitor of Ca2+/calmodulin kinase II, attenuates circadian responses to light. | Golombek, DA. and Ralph, MR. 1994. Neuroreport. 5: 1638-40. PMID: 7819537
- KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes. | Okazaki, K., et al. 1994. J Pharmacol Exp Ther. 270: 1319-24. PMID: 7932185
- The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle. | Minami, H., et al. 1994. Biochem Biophys Res Commun. 199: 241-8. PMID: 8123019
- KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells. | Cui, ZJ., et al. 1996. Biochim Biophys Acta. 1310: 343-7. PMID: 8599613
- Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. | Wei, J., et al. 1996. J Biol Chem. 271: 24231-5. PMID: 8798667
- The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. | Gargett, CE. and Wiley, JS. 1997. Br J Pharmacol. 120: 1483-90. PMID: 9113369
- Effect of KN-62, a selective inhibitor of calmodulin-dependent kinase II, on mouse oocyte activation. | Inagaki, N., et al. 1997. J Assist Reprod Genet. 14: 609-16. PMID: 9447464
Inhibitor of:
4933412E24Rik, Ang-1, ART2, ATP6V0E2, C8β, C8orf31, CaM II, CaMK1γ, CaMKI, CaMKIδ, CaMKII, CaMKIIα, CaMKIIβ, CaMKIIδ, CaMKIIγ, CaMKIIN1, CaMKIIN2, CapZIP, FNDC1, hippocalcin, ICA1L, JP-45, KNDC1, LALP1, LIN-2, neurexin I, Nova-1, Olfr477, Olfr479, Olfr492, Olfr493, Olfr494, Olfr570, Olfr640, Olfr641, Olfr642, Olfr643, Olfr644, Olfr645, Olfr65, Olfr651, Olfr889, Olfr890, Olfr891, Olfr893, Olfr894, Olfr895, Olfr898, Olfr899, Olfr90, Olfr915, Olfr916, Olfr917, Olfr918, Olfr919, Olfr92, Olfr921, P2X3, P2X4, P2X5, P2X7, ProSAPiP1, Protease, QKI, Relaxin 3, Ser/Thr Protein Kinase, Shank 2, Synapsin IIb, TANC2, TAPT1, TBC1D1, Vmn1r157, Vmn2r15, and ZNF440.Activator of:
AI467606, BC028528, CaM V, CaMKKα, CASKIN1, CPEB3, Cypt2, DPY19L2, E130309D02Rik, Gas7, HDA2, IQCC, LOC221710, LSm12, MAGIX, MARK3, NPC Marker, NTN, NTPDase8, NUDT6, OBSL1, OLFML2B, OR1L3, OR1L8, PP2Cκ, RBJ, RIN1, SAPAP1, Serine racemase, translin, ZC3H7A, and Zic2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KN-62, 1 mg | sc-3560 | 1 mg | $136.00 |