KLF6 Antibody (2F5): sc-134374
- KLF6 Antibody (2F5) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant KLF6 protein of human origin
- recommended for detection of KLF6 of human origin by WB, IP and ELISA
- See KLF6 (E-10): sc-365633 for KLF6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KLF6 Antibody (2F5). This work is in progress.
KLF6 Antibody (2F5) is a mouse monoclonal IgG1 antibody that detects KLF6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). KLF6, also known as transcription factor ZF9, B cell derived 1 (BCD1), and core promoter element-binding protein (COPEB), plays a crucial role in regulating gene expression during development and cellular processes. This nuclear DNA-binding protein is primarily expressed in the placenta, where KLF6 is co-expressed with KLF4 and pregnancy glycoprotein in the same cell types of placenta villi and membranes, highlighting its importance in placental development and function. Additionally, KLF6 is involved in reducing cell proliferation by upregulating p21 in a manner that is independent of p53, which is significant for maintaining cellular homeostasis and preventing uncontrolled cell growth. The gene encoding human KLF6 is located on chromosome 10p15 and has been implicated in a subset of human prostate cancer, making KLF6 a valuable target for research in cancer biology and developmental regulation. Anti-KLF6 antibody (2F5) is an essential tool for scientists studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KLF6 Antibody (2F5) References:
- The role of KLF6 and its splice variants in cancer therapy. | DiFeo, A., et al. 2009. Drug Resist Updat. 12: 1-7. PMID: 19097929
- Krüppel-like factor 6 (KLF6) requires its amino terminal domain to promote villous trophoblast cell fusion. | Miranda, AL., et al. 2022. Placenta. 117: 139-149. PMID: 34894601
- Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages. | Tian, S., et al. 2022. Stem Cell Res Ther. 13: 330. PMID: 35858897
- KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy. | Li, J., et al. 2023. Cell Death Dis. 14: 393. PMID: 37391422
- Klf6 aggravates myocardial ischemia/reperfusion injury by activating Acsl4-mediated ferroptosis. | Qiu, ML., et al. 2023. Kaohsiung J Med Sci. 39: 989-1001. PMID: 37530646
- Exosomal miR-181d-5p Derived from Rapamycin-Conditioned MDSC Alleviated Allograft Rejection by Targeting KLF6. | Wei, C., et al. 2023. Adv Sci (Weinh). 10: e2304922. PMID: 37870185
- Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development. | Malin, J., et al. 2023. Sci Adv. 9: eadg8126. PMID: 37967174
- KLF6 activates Sp1-mediated prolidase transcription during TGF-β1 signaling. | Eni-Aganga, I., et al. 2024. J Biol Chem. 300: 105605. PMID: 38159857
- Comprehensive analysis of KLF family reveals KLF6 as a promising prognostic and immune biomarker in pancreatic ductal adenocarcinoma. | Lin, J., et al. 2024. Cancer Cell Int. 24: 177. PMID: 38773440
- Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease. | Gujarati, NA., et al. 2024. Nat Commun. 15: 8038. PMID: 39271683
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLF6 Antibody (2F5) | sc-134374 | 100 µg/ml | $339.00 |