JIP-2 Antibody (B-2): sc-376065

JIP-2 Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects JIP-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JIP-2, a member of the JNK-interacting protein family, plays a crucial role in the regulation of c-Jun NH2-terminal kinases (JNKs) by acting as a scaffold that facilitates the interaction between JNKs and their downstream targets. This interaction is vital for the proper transmission of signals that regulate various cellular processes, including stress responses, apoptosis, and cell differentiation. JIP-2 is predominantly localized in the cytoplasm, where JIP-2 not only modulates JNK activity but also influences the spatial and temporal dynamics of JNK signaling pathways. JIP-2 contains a JNK-binding domain that allows interaction with JNKs, as well as a SH3 domain that can bind to other signaling proteins, thereby integrating multiple signaling pathways. JIP-2′s ability to sequester JNKs in the cytoplasm is particularly important, as this prevents inappropriate activation of JNK-regulated gene expression, which could lead to pathological conditions. With versatile applications and significant role in cellular signaling, JIP-2 (B-2) antibody serves as an essential tool for researchers studying the complexities of JNK signaling and its implications in various diseases.

The preferred JIP-2 antibody is JIP-2 Antibody (A-9): sc-377490.