JFC1 Antibody (E-8): sc-365933
- JFC1 Antibody (E-8) is a mouse monoclonal IgG1 κ JFC1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 473-506 near the C-terminus of JFC1 of human origin
- JFC1 Antibody (E-8) is recommended for detection of JFC1 of human origin by WB, IP, IF and ELISA
- Anti-JFC1 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JFC1 Antibody (E-8) for WB applications. These reagents are now offered in bundles with JFC1 Antibody (E-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
JFC1 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects JFC1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JFC1 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. JFC1, also known as Slp1 (synaptotagmin-like protein), plays a crucial role in vesicular trafficking, which is essential for processes such as neurotransmitter release and hormone secretion. Located at the plasma membrane, JFC1 interacts with the GTP-bound form of Rab27a through its two N-terminal Slp homology domains (SHD1 and SHD2), which are characterized by their conserved α-helical structures. This interaction is vital for the regulation of vesicle transport and fusion, impacting cellular communication and signaling pathways. Additionally, JFC1 is transcriptionally activated by NFκB and is upregulated by TNFα in prostate carcinoma cells, highlighting its potential role in cancer biology. With its ability to bind phosphatidylinositol 3,4,5-triphosphate-binding ATPase, JFC1 is integral to the dynamic processes of membrane trafficking and cellular response, making JFC1 a valuable target for research in both basic and applied sciences.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JFC1 Antibody (E-8) | sc-365933 | 200 µg/ml | $322.00 | |||
JFC1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-529518 | 200 µg Ab; 10 µg BP | $361.00 | |||
JFC1 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-522432 | 200 µg Ab, 40 µg BP | $361.00 | |||
JFC1 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-543557 | 200 µg Ab; 20 µg BP | $361.00 | |||
JFC1 Antibody (E-8) AC | sc-365933 AC | 500 µg/ml, 25% agarose | $424.00 | |||
JFC1 Antibody (E-8) HRP | sc-365933 HRP | 200 µg/ml | $322.00 | |||
JFC1 Antibody (E-8) FITC | sc-365933 FITC | 200 µg/ml | $336.00 | |||
JFC1 Antibody (E-8) PE | sc-365933 PE | 200 µg/ml | $349.00 | |||
JFC1 Antibody (E-8) Alexa Fluor® 488 | sc-365933 AF488 | 200 µg/ml | $364.00 | |||
JFC1 Antibody (E-8) Alexa Fluor® 546 | sc-365933 AF546 | 200 µg/ml | $364.00 | |||
JFC1 Antibody (E-8) Alexa Fluor® 594 | sc-365933 AF594 | 200 µg/ml | $364.00 | |||
JFC1 Antibody (E-8) Alexa Fluor® 647 | sc-365933 AF647 | 200 µg/ml | $364.00 | |||
JFC1 Antibody (E-8) Alexa Fluor® 680 | sc-365933 AF680 | 200 µg/ml | $364.00 | |||
JFC1 Antibody (E-8) Alexa Fluor® 790 | sc-365933 AF790 | 200 µg/ml | $364.00 | |||
JFC1 (E-8) Neutralizing Peptide | sc-365933 P | 100 µg/0.5 ml | $69.00 |