Integrin αV/ITGAV/CD51 Antibody (2Q888): sc-71451

Integrin αV Antibody (2Q888) is a mouse monoclonal IgG1 kappa light chain antibody raised against melanoma cells of human origin, designed for the detection of human Integrin αV by immunofluorescence (IF) and flow cytometry (FCM). Integrin αV, also known as CD51 or ITGAV, is a transmembrane glycoprotein that pairs with various β subunits (β1, β3, β5, β6, and β8) to form functional receptors involved in cell adhesion, migration, and signal transduction. Integrin αV undergoes crucial post-translational modifications, particularly N-linked glycosylation, which is essential for proper folding, stability, and ligand-binding affinity. Glycosylation of Integrin αV influences interaction with extracellular matrix proteins such as vitronectin, fibronectin, and osteopontin, thereby affecting cellular processes like angiogenesis, wound healing, and tumor progression. These post-translational modifications play a key role in modulating protein function and involvement in various physiological and pathological conditions, including cancer metastasis and inflammatory diseases. Anti-Integrin αV antibody (2Q888) recognizes both native and modified forms, serving as a valuable tool for researchers studying protein role and regulation in different cellular contexts. Understanding Integrin αV function, regulation, and post-translational modifications can provide insights into therapeutic targets for diseases where this protein plays a pivotal role.

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Integrin αV/ITGAV/CD51 Antibody (2Q888) References:

1. αV integrins in angiogenesis and cancer.  |  Weis, SM. and Cheresh, DA. 2011. Cold Spring Harb Perspect Med. 1: a006478. PMID: 22229119
2. Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion.  |  Duperret, EK., et al. 2015. J Cell Sci. 128: 3997-4013. PMID: 26359297
3. αv integrins: key regulators of tissue fibrosis.  |  Conroy, KP., et al. 2016. Cell Tissue Res. 365: 511-9. PMID: 27139180
4. SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma.  |  Cai, Q., et al. 2019. J Mol Cell Biol. 11: 421-432. PMID: 30215728
5. Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells.  |  Bouvet, M., et al. 2020. Sci Rep. 10: 11404. PMID: 32647159
6. Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade.  |  Malenica, I., et al. 2021. Nat Commun. 12: 5209. PMID: 34471106
7. Expression of αV integrin and its potential partners in bull reproductive tissues, germ cells and spermatozoa.  |  Antalíková, J., et al. 2022. Int J Biol Macromol. 209: 542-551. PMID: 35413326
8. Development of an integrin αv-based universal marker, capable of both prediction and direction of stem cell fate.  |  Heo, CH., et al. 2023. Acta Biomater. 166: 291-300. PMID: 37137404
9. Overexpression of Integrin alpha V (ITGAV) in gastric cancer and its prognostic significance.  |  Zhang, W., et al. 2023. Asian J Surg. 46: 5863-5864. PMID: 37659950
10. Suppression of OGN in lung myofibroblasts attenuates pulmonary fibrosis by inhibiting integrin αv-mediated TGF-β/Smad pathway activation.  |  Huang, S., et al. 2024. Matrix Biol. 132: 87-97. PMID: 39019241

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.