Integrin αM/CD11b Antibody (44): sc-1186

Integrin αM Antibody (44) is a mouse monoclonal IgG1 kappa light chain antibody specifically targeting Integrin αM, also known as CD11b, ITGAM, Mac-1, or complement component receptor-3 α (CR3α). Anti-Integrin αM antibody (44) recognizes Integrin αM from human, mouse, and rat origins, making it versatile for various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Integrin αM is a crucial cell adhesion molecule that plays a significant role in the immune system by mediating the adherence of neutrophils and monocytes to activated endothelial cells, which is essential for effective immune response and inflammation regulation. Additionally, Integrin αM forms a heterodimer with Integrin β2, creating the leukocyte-specific integrin Mac-1 (CR3), which is vital for the phagocytosis of complement-opsonized pathogens and debris. The proper functioning of Integrin αM is important for maintaining immune surveillance and combating infections, as well as in the pathology of inflammatory diseases such as rheumatoid arthritis and atherosclerosis. Anti-Integrin αM antibody (44) is available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing researchers with flexible options for their experimental needs. By targeting Integrin αM, Integrin αM (44) antibody facilitates the detailed study of immune cell interactions and the mechanisms underlying immune-mediated conditions, making this tool indispensable for immunological research and therapeutic development.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αM/CD11b Antibody (44) has 36 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αM/CD11b Antibody (44) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αM/CD11b Antibody (44) Specifications

Alternate Product Name: ITGAM

Product Clone Name: 44

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin αM

Epitope Species: human

Product Reactivity/Detection: Integrin αM

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 36 citations in various scientific publications

Available Conjugates/Forms for Integrin αM/CD11b Antibody (44): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.