IL-8 Antibody (NYR-HIL8): sc-73321
- IL-8 Antibody (NYR-HIL8) is a mouse monoclonal IgG1, cited in 10 publications, provided at 100 µg/ml
- raised against recombinant IL-8 of human origin
- recommended for detection of IL-8 of human origin by WB, IP and IF
- See IL-8 (C-11): sc-376750 for IL-8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-8 Antibody (NYR-HIL8). This work is in progress.
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IL-8 Antibody (NYR-HIL8) is a mouse monoclonal IgG1 antibody that detects interleukin-8 (IL-8) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IL-8 is a crucial chemokine that plays a significant role in the immune response by acting as a chemoattractant for neutrophils, thereby facilitating their migration to sites of inflammation. This function is particularly important in the context of chronic inflammatory diseases, such as inflammatory bowel disease and atherosclerosis, where elevated levels of IL-8 have been observed. The protein is initially synthesized as a 99 amino acid precursor, which is then cleaved to produce a biologically active 72 amino acid form. Notably, IL-8 exists in both monomeric and dimeric forms, with dimerization serving as a negative regulator of IL-8 receptor function. The receptors for IL-8, IL-8RA and IL-8RB, are seven-transmembrane domain proteins that share a high degree of sequence identity and are also involved in the signaling of other chemokines. Anti-IL-8 antibody (NYR-HIL8) is an essential tool for researchers studying the complex roles of IL-8 in immune responses and its implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-8 Antibody (NYR-HIL8) References:
- Regulation of IL-8 production and the characteristics of the receptors for IL-8. | Mukaida, N. and Matsushima, K. 1992. Cytokines. 4: 41-53. PMID: 1472916
- IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis. | Bao, XB., et al. 2015. Genet Mol Res. 14: 1508-14. PMID: 25730090
- IL-8 Alterations in HIV-1 Infected Children With Disease Progression. | Pananghat, AN., et al. 2016. Medicine (Baltimore). 95: e3734. PMID: 27227934
- IL-8 promotes HNSCC progression on CXCR1/2-meidated NOD1/RIP2 signaling pathway. | Chan, LP., et al. 2016. Oncotarget. 7: 61820-61831. PMID: 27557518
- IL-8 interacts with metadherin promoting proliferation and migration in gastric cancer. | Li, W., et al. 2016. Biochem Biophys Res Commun. 478: 1330-7. PMID: 27565732
- IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity. | Yang, L., et al. 2018. Am J Physiol Lung Cell Mol Physiol. 314: L127-L136. PMID: 28860143
- IL-8 Gene Variants and Expression in Childhood Asthma. | Charrad, R., et al. 2017. Lung. 195: 749-757. PMID: 28993876
- Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5. | Milosevic, V., et al. 2020. Int J Cancer. 146: 192-207. PMID: 31107974
- Hsp60 and IL-8 axis promotes apoptosis resistance in cancer. | Kumar, S., et al. 2019. Br J Cancer. 121: 934-943. PMID: 31673102
- The occurrence and development of vertebral osteoporosis regulated by IL-8. | Zhu, H., et al. 2023. Medicine (Baltimore). 102: e35680. PMID: 37933016
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-8 Antibody (NYR-HIL8) | sc-73321 | 100 µg/ml | $322.00 |