IL-12 p70 Antibody (QS-12p70): sc-57257
- IL-12 p70 Antibody (QS-12p70) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against full length IL-12 of human origin
- recommended for detection of IL-12 p70 heterodimer of human origin by ELISA; non cross-reactive with the p35 or p40 monomer
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-12 p70 Antibody (QS-12p70). This work is in progress.
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IL-12 p70 Antibody (QS-12p70) is a mouse monoclonal IgG1 antibody that detects interleukin-12 p70 in human samples through enzyme-linked immunosorbent assay (ELISA). Interleukin-12 p70 (IL-12 p70) plays a crucial role in the immune response by promoting the differentiation of naive CD4(+) T cells into type 1 helper T cells, which are essential for the production of interferon-γ (IFN-γ). IL-12 p70 enhances the immune system′s ability to combat infections and tumors by activating natural killer (NK) cells and stimulating the production of tumor necrosis factor α (TNF-α). IL-12 p70 inhibits the suppressive effects of interleukin-4 on IFN-γ production, thereby ensuring a robust immune response. IL-12 p70 regulation is complex, as production occurs in response to various pathogens and is controlled by both p35 and p40 subunits in a cell type-specific manner. IL-12 p70′s ability to enhance immune responses and involvement in anti-angiogenic activity, through the induction of proteins like inducible protein-10 (IP-10), underscores its importance in immunological research and therapeutic applications.
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IL-12 p70 Antibody (QS-12p70) References:
- Early IL-12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood-stage Plasmodium chabaudi AS malaria. | Sam, H. and Stevenson, MM. 1999. Clin Exp Immunol. 117: 343-9. PMID: 10444268
- CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. | Schulz, O., et al. 2000. Immunity. 13: 453-62. PMID: 11070164
- IL-12 and IL-18 are increased and stimulate IFN-gamma production in sarcoid lungs. | Shigehara, K., et al. 2001. J Immunol. 166: 642-9. PMID: 11123348
- Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity. | Lauwerys, BR., et al. 2002. Lupus. 11: 384-7. PMID: 12139377
- Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70. | Suzuki, K., et al. 2003. Exerc Immunol Rev. 9: 48-57. PMID: 14686094
- Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70. | Jana, M. and Pahan, K. 2009. Immunology. 127: 312-25. PMID: 19019087
- IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. | Jana, M. and Pahan, K. 2009. Mol Immunol. 46: 773-83. PMID: 19100623
- IL-12B Gene Polymorphisms and IL-12 p70 Serum Levels Among Patients with Rheumatoid Arthritis. | Paradowska-Gorycka, A., et al. 2017. Scand J Immunol. 85: 147-154. PMID: 27896842
- IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial. | Moll-Bernardes, R., et al. 2021. Front Cardiovasc Med. 8: 702507. PMID: 34386533
- A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells. | Cubitt, CC., et al. 2022. Mol Ther Oncolytics. 24: 585-596. PMID: 35284622
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-12 p70 Antibody (QS-12p70) | sc-57257 | 100 µg/ml | $322.00 |