Molecular structure of GYKI 52466 hydrochloride, CAS Number: 102771-26-6
GYKI 52466 hydrochloride (CAS 102771-26-6)
Alternate Names:
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Application:
GYKI 52466 hydrochloride is a selective non-competitive allosteric AMPA receptor antagonist
CAS Number:
102771-26-6
Purity:
≥98%
Molecular Weight:
329.78
Molecular Formula:
C17H15N3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GYKI 52466 hydrochloride is a selective non-competitive allosteric AMPA receptor antagonist. It exhibits anti-proliferative effects in transformed cells. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
GYKI 52466 hydrochloride (CAS 102771-26-6) References
- Kainate-triggered currents in Xenopus oocytes injected with chick retinal membrane fragments: effect of guanine nucleotides. | Burgos, JS., et al. 2003. Invest Ophthalmol Vis Sci. 44: 3124-9. PMID: 12824261
- GYKI 52466 blocks the increase in extracellular glutamate induced by ischaemia. | Arvin, B., et al. 1992. Neuroreport. 3: 235-8. PMID: 1355369
- Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release. | Avshalumov, MV. and Rice, ME. 2003. Proc Natl Acad Sci U S A. 100: 11729-34. PMID: 13679582
- Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat. | Smith, SE. and Meldrum, BS. 1992. Stroke. 23: 861-4. PMID: 1595106
- Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake. | Le Merrer, J. and Stephens, DN. 2006. J Neurosci. 26: 7163-71. PMID: 16822973
- Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex. | West, PJ., et al. 2007. Neuroscience. 146: 1000-12. PMID: 17395391
- The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. | Du, J., et al. 2008. J Neurosci. 28: 68-79. PMID: 18171924
- Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. | Borbély, S., et al. 2009. Neuroscience. 159: 358-68. PMID: 19154779
- Peripheral ammonia as a mediator of methamphetamine neurotoxicity. | Halpin, LE. and Yamamoto, BK. 2012. J Neurosci. 32: 13155-63. PMID: 22993432
- Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats. | Tóth, Z., et al. 2018. Acta Histochem. 120: 236-241. PMID: 29478811
- The non-competitive AMPA/kainate receptor antagonist, GYKI 52466, potentiates the anticonvulsant activity of conventional antiepileptics. | Borowicz, KK., et al. 1995. Eur J Pharmacol. 281: 319-26. PMID: 8521916
- GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice. | de Sarro, G., et al. 1995. Eur J Pharmacol. 294: 411-22. PMID: 8750701
- Protection against non-NMDA receptor-mediated excitotoxicity by GYKI 52466 in mature telencephalic cultures of the rat. | Kovács, AD. and Egyed, A. 1996. Neurobiology (Bp). 4: 59-72. PMID: 9116695
- AMPA-preferring receptors mediate excitatory synaptic inputs to retinal ganglion cells. | Lukasiewicz, PD., et al. 1997. J Neurophysiol. 77: 57-64. PMID: 9120596
- GYKI 52466 [1-(4-aminophenyl)-4-methoxy-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the anticonvulsive activity of conventional antiepileptics against pentetrazol in mice. | Czuczwar, SJ., et al. 1998. Mol Chem Neuropathol. 33: 149-62. PMID: 9642669
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GYKI 52466 hydrochloride, 10 mg | sc-203591 | 10 mg | $173.00 | |||
GYKI 52466 hydrochloride, 25 mg | sc-203591A | 25 mg | $428.00 |