GRPR Antibody (D-1): sc-398549

GRPR Antibody (D-1) is a mouse monoclonal IgG2b antibody that detects GRPR protein of mouse, rat, human, and hamster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRPR (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Gastrin-Releasing Peptide Receptor (GRPR) plays a crucial role in gastrointestinal physiology by stimulating the release of gastrin and other hormones, which are essential for digestive processes. Additionally, GRPR acts as an autocrine growth factor for specific cell types, highlighting its importance in cellular signaling and growth regulation. The human GRPR gene is located on chromosome Xp21.2-p22.3 and encodes a protein characterized by seven transmembrane domains, which is vital for its function as a receptor. While GRPR is expressed in normal human pancreas and stomach tissues, GRPR is notably absent in normal lung, colon, and prostate tissues. Interestingly, well-differentiated colon tumors have been found to coexpress both GRP and GRPR, and prostate carcinoma also shows GRPR expression. Furthermore, exposure to nicotine has been shown to increase GRPR expression in human lung fibroblasts, and aberrant GRPR expression is more prevalent in female normal lung tissue compared to male, potentially contributing to the heightened susceptibility of women to tobacco-induced lung cancer.

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GRPR Antibody (D-1) References:

1. Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans.  |  Carroll, RE., et al. 1999. Am J Physiol. 276: G655-65. PMID: 10070042
2. Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.  |  Shriver, SP., et al. 2000. J Natl Cancer Inst. 92: 24-33. PMID: 10620630
3. Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers.  |  Sun, B., et al. 2000. Prostate. 42: 295-303. PMID: 10679759
4. The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter.  |  Xiao, D., et al. 2001. Gene. 264: 95-103. PMID: 11245983
5. Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor.  |  Spindel, ER., et al. 1990. Mol Endocrinol. 4: 1956-63. PMID: 1707129
6. GRPR/PI3Kγ: Partners in Central Transmission of Itch.  |  Pereira, PJ., et al. 2015. J Neurosci. 35: 16272-81. PMID: 26658875
7. Novel insight on GRP/GRPR axis in diseases.  |  Sun, HL., et al. 2023. Biomed Pharmacother. 161: 114497. PMID: 36933382
8. The GRPR Antagonist [99mTc]Tc-maSSS-PEG2-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity.  |  Abouzayed, A., et al. 2023. Diagnostics (Basel). 13: PMID: 37175001
9. GRP/GRPR enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway.  |  Li, H., et al. 2024. Hepatology. 79: 392-408. PMID: 37409771
10. Comparative mapping of the Grpr locus on the X chromosomes of man and mouse.  |  Maslen, GL. and Boyd, Y. 1993. Genomics. 17: 106-9. PMID: 8406441
11. Physiology of isolated gastric endocrine cells.  |  Sachs, G., et al. 1997. Annu Rev Physiol. 59: 243-56. PMID: 9074763
12. Growth stimulation of normal melanocytes and nevocellular nevus cells by gastrin releasing peptide (GRP).  |  Terashi, H., et al. 1998. J Dermatol Sci. 17: 93-100. PMID: 9673890

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GRPR Antibody (D-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GRPR Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GRPR Antibody (D-1) Specifications

Alternate Product Name: Gastrin Releasing Peptide Receptor

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b lambda light chain

Amino Acids: 1-50

Epitope Target: GRPR

Epitope Species: mouse

Product Reactivity/Detection: GRPR

Species Reactivity/Detection: mouse, rat, human, hamster

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GRPR Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin