GLP-1R Antibody (D-6): sc-390774

GLP-1R Antibody (D-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects GLP-1R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GLP-1R (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GLP-1R protein plays a crucial role in glucose metabolism and appetite regulation, as GLP-1R is primarily located in the hypothalamus, a brain region that governs feeding behavior. This localization is significant because GLP-1R mediates the effects of glucagon-like peptide-1 (GLP-1), which not only enhances insulin secretion but also suppresses appetite, making GLP-1R a vital target for diabetes and obesity therapies. The interaction between GLP-1 and GLP-1R is essential for maintaining glucose homeostasis, and dysregulation of this pathway can lead to metabolic disorders. Anti-GLP-1R antibody (D-6) enables researchers to explore the intricate mechanisms of GLP-1 signaling and its implications in metabolic health.

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GLP-1R Antibody (D-6) References:

1. Glucagon and regulation of glucose metabolism.  |  Jiang, G. and Zhang, BB. 2003. Am J Physiol Endocrinol Metab. 284: E671-8. PMID: 12626323
2. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.  |  Qureshi, SA., et al. 2004. Diabetes. 53: 3267-73. PMID: 15561959
3. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.  |  Gromada, J., et al. 2004. Basic Clin Pharmacol Toxicol. 95: 252-62. PMID: 15569269
4. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem.  |  Alvarez, E., et al. 2005. J Neurochem. 92: 798-806. PMID: 15686481
5. Characterization of the glucagon receptor and its functional domains using monoclonal antibodies.  |  Iwanij, V. and Vincent, AC. 1990. J Biol Chem. 265: 21302-8. PMID: 2174441
6. Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.  |  Killion, EA., et al. 2018. Sci Transl Med. 10: PMID: 30567927
7. Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice.  |  Desjardins, EM., et al. 2023. Cell Rep Med. 4: 101193. PMID: 37729871
8. The dual GCGR/GLP-1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection.  |  Thomas, L., et al. 2024. Diabetes Obes Metab. 26: 2368-2378. PMID: 38560764
9. GLP-1R agonist medications for addiction treatment.  |  Volkow, ND. and Xu, R. 2025. Addiction. 120: 198-200. PMID: 39049203
10. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.  |  Rouillé, Y., et al. 1995. J Biol Chem. 270: 26488-96. PMID: 7592866
11. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.  |  Scrocchi, LA., et al. 1996. Nat Med. 2: 1254-8. PMID: 8898756
12. Specific features of glycogen metabolism in the liver.  |  Bollen, M., et al. 1998. Biochem J. 336 (Pt 1): 19-31. PMID: 9806880

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GLP-1R Antibody (D-6) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-GLP-1R Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GLP-1R Antibody (D-6) Specifications

Alternate Product Name: glucagon-like peptide-1 G-protein coupled receptor

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 91-145

Epitope Target: GLP-1R

Epitope Species: human

Product Reactivity/Detection: GLP-1R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for GLP-1R Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred GLP-1R antibody is GLP-1R Antibody (B-11): sc-390773.