GABP-α Antibody (8C1B10): sc-134222
- GABP-α Antibody (8C1B10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 120-190 of GABP-α of human origin
- recommended for detection of GABP-α of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GABP-α Antibody (8C1B10). This work is in progress.
GABP-α Antibody (8C1B10) is a mouse monoclonal IgG1 antibody that detects GABP-α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). GABP-α, a critical transcription factor, plays a vital role in regulating gene expression by binding to specific DNA sequences, thereby influencing various cellular processes. GABP-α is primarily located in the nucleus, where GABP-α forms a heterodimer with GABPβ, which can exist in two splice variants, b1 and b2, that differ in their C-termini. Nuclear localization of GABP-α is essential for transcriptional regulation, allowing direct interaction with DNA and other transcriptional machinery. GABP-α is involved in coordinating mitochondrial and nuclear transcription, particularly for cytochrome oxidase in neurons, highlighting GABP-α′s importance in cellular energy metabolism. Anti-GABP-α antibody (8C1B10) serves as an invaluable tool for researchers studying gene regulation mechanisms and GABP-α′s role in various biological processes.
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GABP-α Antibody (8C1B10) References:
- GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells. | Kinoshita, K., et al. 2007. Biochem Biophys Res Commun. 353: 686-91. PMID: 17194449
- Targeting of the ETS factor GABPalpha disrupts neuromuscular junction synaptic function. | O'Leary, DA., et al. 2007. Mol Cell Biol. 27: 3470-80. PMID: 17325042
- Neuregulin-1 induces acetylcholine receptor transcription in the absence of GABPalpha phosphorylation. | Herndon, CA. and Fromm, L. 2008. J Neurosci Res. 86: 982-91. PMID: 17975830
- Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. | Chandele, A., et al. 2008. J Immunol. 180: 5309-19. PMID: 18390712
- The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer. | Sharma, NL., et al. 2014. Nucleic Acids Res. 42: 6256-69. PMID: 24753418
- Expression of the ETS transcription factor GABPα is positively correlated to the BCR-ABL1/ABL1 ratio in CML patients and affects imatinib sensitivity in vitro. | Manukjan, G., et al. 2015. Exp Hematol. 43: 880-90. PMID: 26072332
- GABPα Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1: Custom DNA Microarrays. | He, X., et al. 2015. G3 (Bethesda). 5: 1909-18. PMID: 26185160
- GABPα and CREB1 Binding to Double Nucleotide Polymorphisms of Their Consensus Motifs and Cooperative Binding to the Composite ETS ⇔ CRE Motif (ACCGGAAGTGACGTCA). | Assad, N., et al. 2019. ACS Omega. 4: 9904-9910. PMID: 34151054
- The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. | Batchelor, AH., et al. 1998. Science. 279: 1037-41. PMID: 9461436
- Synapse-specific and neuregulin-induced transcription require an ets site that binds GABPalpha/GABPbeta. | Fromm, L. and Burden, SJ. 1998. Genes Dev. 12: 3074-83. PMID: 9765208
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GABP-α Antibody (8C1B10) | sc-134222 | 200 µg/ml | $322.00 |