FGF-2 Antibody (A-7): sc-74413

FGF-2 Antibody (A-7) is a mouse monoclonal IgG2a antibody that detects fibroblast growth factor-2 (FGF-2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FGF-2 plays a crucial role in various biological processes, including angiogenesis, wound healing, and tissue repair, by promoting cell proliferation and differentiation. FGF-2 is primarily located in the extracellular space, where FGF-2 binds to specific fibroblast growth factor receptors (FGFRs) on the cell surface, initiating signaling cascades that influence cellular behavior. The interaction between FGF-2 and FGFRs is vital for normal development and tissue homeostasis, as dysregulation of this pathway can lead to pathological conditions such as cancer and cardiovascular diseases. Anti-FGF-2 antibody (A-7) is an essential tool for researchers studying these critical processes, allowing for the exploration of FGF-2′s role in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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FGF-2 Antibody (A-7) References:

1. PLAP-1/Asporin Positively Regulates FGF-2 Activity.  |  Awata, T., et al. 2015. J Dent Res. 94: 1417-24. PMID: 26239644
2. FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.  |  Ikpegbu, E., et al. 2018. J Cell Physiol. 233: 5334-5347. PMID: 29215722
3. VEGF and FGF-2: Promising targets for the treatment of respiratory disorders.  |  Laddha, AP. and Kulkarni, YA. 2019. Respir Med. 156: 33-46. PMID: 31421589
4. The Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review.  |  Novais, A., et al. 2021. Cells. 10: PMID: 33920587
5. FGF-2 suppresses neuronal autophagy by regulating the PI3K/Akt pathway in subarachnoid hemorrhage.  |  Wang, Y., et al. 2021. Brain Res Bull. 173: 132-140. PMID: 34023434
6. FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis.  |  Mathes, S., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34493647
7. Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature.  |  Dolivo, DM. 2022. J Mol Med (Berl). 100: 847-860. PMID: 35484303
8. FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts.  |  Tsugeno, Y., et al. 2022. Sci Rep. 12: 16006. PMID: 36163231
9. Improved Production of Anti-FGF-2 Nanobody Using Pichia pastoris and Its Effect on Antiproliferation of Keratinocytes and Alleviation of Psoriasis.  |  Zhou, Z., et al. 2023. Arch Immunol Ther Exp (Warsz). 71: 20. PMID: 37632545
10. Mechanical stress-induced FGF-2 promotes proliferation and consequently induces osteoblast differentiation in mesenchymal stem cells.  |  Ogura, H., et al. 2023. Biochem Biophys Res Commun. 684: 149145. PMID: 37913587

The preferred FGF-2 antibody is FGF-2 Antibody (C-2): sc-74412.