Farnesyl pyrophosphate ammonium salt, in ethanol CAS: 13058-04-3
MF: C15H25O7P2•3NH4
MW: 433.42
An isoprenoid farnesyl donor.

Farnesyl pyrophosphate ammonium salt, in ethanol (CAS 13058-04-3)

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Synonym FPP.3NH4
Anwendungen An isoprenoid farnesyl donor
CAS Nummer: 13058-04-3
Reinheit: ≥98%
Molekulargewicht: 433.42
Summenformel: C15H25O7P23NH4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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Farnesyl pyrophosphate ammonium salt, in ethanol, is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP has been shown to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. FPP has also been detected in Alzheimer′s patients brains in elevated levels. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: 2 mg/mL in 0.25M ammonium bicarbonate containing 70% ethanol.


Literaturhinweise

1. Pompliano, D.L., et al. 1992. Biochemistry. 31: 3800-3807. PMID: 1567835
2. Reiss, Y., et al. 1992. J. Biol. Chem. 267: 6403-6408. PMID: 1556143
3. Gauthaman, K., et al. 2009. Br. J. Pharmacol. 157: 962-973. PMID: 19438511
4. Ye, Y., et al. 2009. FEBS Lett. 583: 2997-3003. PMID: 19716825
5. Mather, A., et al. 2009. Int. J. Biochem. Cell Biol. 41: 561-569. PMID: 18692592
6. Hooff, G.P., et al. 2010. Biochim Biophys Acta.180: 896-905. PMID: 20382260

Gebrauch :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Formulierung :
0.25M ammonium bicarbonate containing 70% ethanol
Aggregatzustand :
Liquid
Löslichkeit :
Soluble in water.
LAGERUNG: :
Store at -20° C
Sidepunkt :
78° C
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK :
1
PubChem CID :
71299715
MDL-Nummer :
MFCD00189688
SMILES :
CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C.N.N.N

SDS (MSDS) herunterladen

Analysenzertifikat

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