EVL Antibody (B-1): sc-376943

EVL Antibody (B-1) is a mouse monoclonal IgG1 antibody that detects EVL (Ena/VASP-like protein) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). EVL plays a crucial role in cell motility and cytoskeletal dynamics, as EVL (B-1) antibody recognizes an actin-binding protein belonging to the Mena/VASP protein family. EVL is primarily located at the tips of filopodia and at the leading edge of lamellipodia and focal adhesions, which are essential for cellular movement and adhesion. EVL localization allows for precise regulation of actin filament assembly and disassembly, which is vital for processes such as wound healing, immune response, and neuronal development. Structurally, EVL contains an N-terminal EVH1 domain, a proline-rich core, and a C-terminal EVH2 domain, which facilitate interactions with other proteins, including the SH3 domain of spectrin α II and the LIM domain of TES. These interactions are critical for maintaining cytoskeletal integrity and ensuring proper cellular function. Anti-EVL antibody (B-1) serves as a valuable tool for researchers studying mechanisms of cell motility and cytoskeletal organization in various biological contexts.

The preferred EVL antibody is EVL Antibody (C-12): sc-373793.