ERCC1 Antibody (SPM243): sc-56386
- ERCC1 Antibody (SPM243) is a mouse monoclonal IgG2b, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against recombinant full length ERCC1 of human origin
- recommended for detection of ERCC1 of human and rat origin by WB, IP, IF, IHC(P) and ELISA
- See ERCC1 (D-10): sc-17809 for ERCC1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERCC1 Antibody (SPM243). This work is in progress.
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SEE ALSO...
ERCC1 Antibody (SPM243) is a mouse monoclonal IgG2b antibody that detects ERCC1 in human and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ERCC1 plays a crucial role in the nucleotide excision repair pathway, which is essential for maintaining genomic stability by repairing DNA damage caused by ultraviolet light and other environmental factors. ERCC1 forms a heterodimer with XPF, another key player in this repair process, and together they function as a structure-specific endonuclease that incises damaged DNA. This incisional activity is vital for the removal of bulky DNA adducts, thereby preventing mutations that could lead to skin cancer and other genetic disorders. The significance of ERCC1 in DNA repair highlights its potential as a biomarker for cancer susceptibility and as a target for therapeutic interventions aimed at enhancing DNA repair mechanisms in affected individuals. Anti-ERCC1 antibody (SPM243) serves as an invaluable tool for researchers studying DNA repair processes and their implications in disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERCC1 Antibody (SPM243) | sc-56386 | 50 µg/0.5 ml | $322.00 |