ErbB4/HER4 Antibody (G-6): sc-514462

ErbB-4 Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ErbB-4 plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation, making ErbB-4 a significant player in various physiological processes and a potential target in cancer research. ErbB-4 is primarily located in the cell membrane, where ErbB-4 functions as a receptor tyrosine kinase. Upon ligand binding, ErbB-4 can form homodimers or heterodimers with other members of the EGF receptor family, which is essential for initiating downstream signaling cascades that influence cellular responses. ErbB-4 expression is particularly high in breast carcinoma cell lines, as well as in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum, highlighting ErbB-4′s importance in both normal physiology and disease states. Anti-ErbB-4 antibody (G-6) allows researchers to explore ErbB-4′s role in various biological contexts, including involvement in cancer progression and therapeutic resistance.

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ErbB4/HER4 Antibody (G-6) References:

1. A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells.  |  Uchida, T., et al. 1999. Biochem Biophys Res Commun. 266: 593-602. PMID: 10600548
2. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers.  |  Srinivasan, R., et al. 2000. Cancer Res. 60: 1483-7. PMID: 10749108
3. Estrogen receptor-alpha and C-ERBB-4 expression in breast carcinomas.  |  Suo, Z., et al. 2001. Virchows Arch. 439: 62-9. PMID: 11499842
4. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.  |  Weggen, S., et al. 2003. J Biol Chem. 278: 30748-54. PMID: 12777371
5. Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC.  |  Di Segni, A., et al. 2005. J Mol Neurosci. 26: 57-69. PMID: 15968086
6. Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain.  |  Bernstein, HG., et al. 2006. Brain Res Bull. 69: 546-59. PMID: 16647583
7. Expression of c-erbB-4 in medulloblastoma and its correlation with prognosis.  |  Bal, MM., et al. 2006. Histopathology. 49: 92-3. PMID: 16842254
8. Nuclear and cytoplasmic expression of ErbB-4 in prostate cancer.  |  Ben-Yosef, R., et al. 2007. Int J Biol Markers. 22: 181-5. PMID: 17922460
9. Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.  |  Riese, DJ., et al. 1996. Oncogene. 12: 345-53. PMID: 8570211
10. Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.  |  Vecchi, M., et al. 1998. J Biol Chem. 273: 20589-95. PMID: 9685416

The preferred ErbB4/HER4 antibody is ErbB4/HER4 Antibody (C-7): sc-8050.