epsin 1 Antibody (B-12): sc-365914

Epsin 1 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects Epsin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Epsin 1 plays a crucial role in clathrin-mediated endocytosis, which is essential for the internalization of membrane proteins and lipids, thereby regulating various cellular functions, including signal transduction and nutrient uptake. Epsin 1 is primarily located at the leading edge of clathrin-coated pits, where Epsin 1 facilitates membrane invagination, a critical step in vesicle formation. Epsin 1 contains an epsin N-terminal homology (ENTH) domain that is vital for membrane binding and curvature induction, as well as a Clathrin-binding motif that ensures proper interaction with clathrin and other endocytic proteins. The dynamic localization and function of Epsin 1 underscore its importance in maintaining cellular homeostasis and responding to extracellular signals, making Epsin 1 a significant target for research in cellular biology and related fields. Anti-Epsin 1 antibody (B-12) is an invaluable tool for studying endocytosis mechanisms and Epsin 1′s role in various physiological and pathological processes.

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epsin 1 Antibody (B-12) References:

1. Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis.  |  Praefcke, GJ., et al. 2004. EMBO J. 23: 4371-83. PMID: 15496985
2. Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy.  |  Yao, PJ., et al. 2006. J Comp Neurol. 494: 368-79. PMID: 16320245
3. Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1.  |  Song, J., et al. 2006. Plant Cell. 18: 2258-74. PMID: 16905657
4. Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.  |  Chen, B., et al. 2011. J Biol Chem. 286: 40760-70. PMID: 21965661
5. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.  |  Chen, B., et al. 2014. J Biol Chem. 289: 1580-91. PMID: 24297163
6. Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine.  |  Mizrachi Nebenzahl, Y., et al. 2016. PLoS One. 11: e0150320. PMID: 26990554
7. Epsin1 modulates synaptic vesicle retrieval capacity at CNS synapses.  |  Kyung, JW., et al. 2016. Sci Rep. 6: 31997. PMID: 27557559
8. The N-terminal homology (ENTH) domain of Epsin 1 is a sensitive reporter of physiological PI(4,5)P2 dynamics.  |  Leitner, MG., et al. 2019. Biochim Biophys Acta Mol Cell Biol Lipids. 1864: 433-442. PMID: 30670192
9. Identification of Epsin1 as a regulator for hepatic lipid and glucose metabolism.  |  Huang, X., et al. 2023. Genes Dis. 10: 72-75. PMID: 37013064
10. Epsin1-mediated exosomal sorting of Dll4 modulates the tubular-macrophage crosstalk in diabetic nephropathy.  |  Liu, JL., et al. 2023. Mol Ther. 31: 1451-1467. PMID: 37016580

The preferred epsin 1 antibody is epsin 1 Antibody (C-11): sc-55556.