Ep-CAM Antibody (KS1/4): sc-33687

Ep-CAM Antibody (KS1/4) is a mouse monoclonal IgG2a antibody that detects Ep-CAM in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Ep-CAM, also known as tumor-associated calcium signal transducer 1 and MK-1, is a monomeric membrane glycoprotein predominantly expressed in normal human epithelial tissues and various carcinomas, making Ep-CAM a significant marker for cancer research. Anti-Ep-CAM antibody (KS1/4) recognizes a protein that plays a crucial role in cell adhesion, which is vital for maintaining tissue integrity and regulating cellular signaling pathways. Ep-CAM′s structure includes an extracellular domain with two epidermal growth factor-like repeats, which are essential for adhesive properties, and a cysteine-poor region that contributes to stability and function. Notably, Ep-CAM is often overexpressed in a range of solid tumors, highlighting Ep-CAM′s potential as a therapeutic target and biomarker for cancer diagnosis and treatment. Ep-CAM monoclonal antibody (KS1/4) serves as an invaluable tool for researchers exploring Ep-CAM′s role in cancer biology and potential applications in targeted therapies.

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Ep-CAM Antibody (KS1/4) References:

1. Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM).  |  Tsaktanis, T., et al. 2015. J Biol Chem. 290: 24574-91. PMID: 26292218
2. Expression of epithelial cell adhesion molecule (EpCAM) in oral squamous cell carcinoma.  |  Sen, S. and Carnelio, S. 2016. Histopathology. 68: 897-904. PMID: 26401964
3. Concise Review: Aggressive Colorectal Cancer: Role of Epithelial Cell Adhesion Molecule in Cancer Stem Cells and Epithelial-to-Mesenchymal Transition.  |  Boesch, M., et al. 2018. Stem Cells Transl Med. 7: 495-501. PMID: 29667344
4. Epithelial cell adhesion molecule (EpCAM) from pleural fluid cell lysates is a highly accurate diagnostic biomarker of adenocarcinomatous effusions.  |  Porcel, JM., et al. 2019. Respirology. 24: 799-804. PMID: 30903651
5. CD133 and epithelial cell adhesion molecule expressions in the cholangiocarcinoma component are prognostic factors for combined hepatocellular cholangiocarcinoma.  |  Wakizaka, K., et al. 2020. Hepatol Res. 50: 258-267. PMID: 31661725
6. Expression level of epithelial cell adhesion molecule (EpCAM) of circulating tumor cells (CTCs) of patients with NSCLC as an early indicator to monitor the effects of postoperative adjuvant chemotherapy.  |  Zhen, Z., et al. 2021. Transl Cancer Res. 10: 3299-3305. PMID: 35116636
7. Loss of TROP2 and epithelial cell adhesion molecule expression is linked to grade progression in pTa but unrelated to disease outcome in pT2-4 urothelial bladder carcinomas.  |  Müller, JH., et al. 2023. Front Oncol. 13: 1342367. PMID: 38282671
8. Immunolocalization of epithelial cell adhesion molecule and matrix metalloproteinase-9 in oral epithelial dysplasia and oral squamous cell carcinoma.  |  Maurya, SB., et al. 2023. J Cancer Res Ther. 19: 1775-1780. PMID: 38376277
9. Epithelial Cell Adhesion Molecule (EpCAM) Expression in Human Tumors: A Comparison with Pan-Cytokeratin and TROP2 in 14,832 Tumors.  |  Menz, A., et al. 2024. Diagnostics (Basel). 14: PMID: 38786342
10. Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins.  |  Litvinov, SV., et al. 1997. J Cell Biol. 139: 1337-48. PMID: 9382878

The preferred Ep-CAM antibody is Ep-CAM Antibody (C-10): sc-25308.