Endoglin/CD105 Antibody (8E11): sc-53999
- Endoglin/CD105 Antibody (8E11) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against monocytic U937 phorbol ester-treated cells of human origin
- recommended for detection of Endoglin of human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Endoglin/CD105 (P3D1): sc-18838 for Endoglin/CD105 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Endoglin/CD105 Antibody (8E11) for WB applications. This reagent is now offered in a bundle with Endoglin/CD105 Antibody (8E11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
Endoglin Antibody (8E11) is a mouse monoclonal IgM antibody that detects Endoglin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Endoglin, also known as CD105, plays a crucial role in angiogenesis and vascular remodeling, making Endoglin essential for maintaining normal blood vessel structure and function. CD105 is predominantly located on the surface of vascular endothelial cells, where CD105 interacts with members of the transforming growth factor-beta (TGF-β) superfamily, facilitating the regulation of endothelial cell proliferation and migration. Endoglin′s location in the cell is critical, as Endoglin expression is vital for proper formation of blood vessels and prevention of vascular malformations, which are characteristic of hereditary hemorrhagic telangiectasia (HHT). Mutations in the Endoglin gene lead to impaired signaling pathways that contribute to vascular abnormalities seen in HHT, highlighting CD105′s significance in both health and disease. Anti-Endoglin antibody (8E11) is an invaluable tool for researchers studying vascular biology and related disorders, providing insights into mechanisms underlying endothelial function and pathogenesis of vascular diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endoglin/CD105 Antibody (8E11) | sc-53999 | 200 µg/ml | $322.00 | |||
Endoglin/CD105 Antibody (8E11): m-IgGκ BP-HRP Bundle | sc-534214 | 200 µg Ab; 40 µg BP | $361.00 | |||
Endoglin/CD105 Antibody (8E11) FITC | sc-53999 FITC | 200 µg/ml | $336.00 | |||
Endoglin/CD105 Antibody (8E11) PE | sc-53999 PE | 200 µg/ml | $349.00 |