EMMPRIN/CD147 Antibody (A-12): sc-25273
- EMMPRIN/CD147 Antibody (A-12) is a mouse monoclonal IgG2a κ, cited in 10 publications, provided at 200 µg/ml
- raised against amino acids 1-200 of EMMPRIN of human origin
- recommended for detection of EMMPRIN of mouse, rat and human origin by WB, IP, IF and ELISA
- See EMMPRIN/CD147 (B-5): sc-46700 for EMMPRIN/CD147 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for EMMPRIN/CD147 Antibody (A-12) for WB applications. These reagents are now offered in bundles with EMMPRIN/CD147 Antibody (A-12) (see ordering information below).
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EMMPRIN Antibody (A-12) is a mouse monoclonal IgG2a antibody that detects EMMPRIN in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EMMPRIN, also known as basigin or CD147, plays a crucial role in regulating matrix remodeling at the epidermal-dermal interface by stimulating fibroblasts to produce various matrix metalloproteinases (MMPs), including interstitial collagenase, gelatinase A, and stromelysin-1. These enzymes are particularly significant during tissue degradation and wound healing, facilitating the breakdown of extracellular matrix components essential for normal physiological processes. Dysregulation of EMMPRIN and associated MMPs has been implicated in cancer invasion and metastasis, making anti-EMMPRIN antibody (A-12) a vital tool for understanding tumor progression and developing therapeutic strategies. EMMPRIN (A-12) antibody provides researchers with reliable detection capabilities when investigating this protein′s complex roles in various biological contexts, including cancer research and tissue repair mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EMMPRIN/CD147 Antibody (A-12) References:
- EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. | Gabison, EE., et al. 2005. Biochimie. 87: 361-8. PMID: 15781323
- Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases. | Seizer, P., et al. 2014. Cardiovasc Res. 102: 17-23. PMID: 24518139
- EMMPRIN in gynecologic cancers: pathologic and therapeutic aspects. | Liu, DT. 2015. Tumour Biol. 36: 4883-8. PMID: 25967458
- The role of EMMPRIN in T cell biology and immunological diseases. | Hahn, JN., et al. 2015. J Leukoc Biol. 98: 33-48. PMID: 25977287
- CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis. | Xin, X., et al. 2016. Sci Rep. 6: 32804. PMID: 27608940
- Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease. | von Ungern-Sternberg, SNI., et al. 2018. Int J Mol Sci. 19: PMID: 29419744
- Role of CD147 (EMMPRIN/Basigin) in Tissue Remodeling. | Guindolet, D. and Gabison, EE. 2020. Anat Rec (Hoboken). 303: 1584-1589. PMID: 30768865
- EMMPRIN-CypA contributes to the inflammatory processes in human periodontitis through infiltrating CD68+ inflammatory cells. | Xue, L., et al. 2018. Int J Clin Exp Pathol. 11: 3828-3834. PMID: 31949770
- EMMPRIN expression is associated with metastatic progression in osteosarcoma. | Kim, HS., et al. 2021. BMC Cancer. 21: 1059. PMID: 34565336
- Crosstalk Between Matrix Metalloproteinases and Their Inducer EMMPRIN/CD147: a Promising Therapeutic Target for Intracerebral Hemorrhage. | Liu, Y., et al. 2023. Transl Stroke Res.. PMID: 38100014
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EMMPRIN/CD147 Antibody (A-12) | sc-25273 | 200 µg/ml | $322.00 | |||
EMMPRIN/CD147 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-536697 | 200 µg Ab; 10 µg BP | $361.00 | |||
EMMPRIN/CD147 Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-533857 | 200 µg Ab; 40 µg BP | $361.00 | |||
EMMPRIN/CD147 Antibody (A-12): m-IgG2a BP-HRP Bundle | sc-547848 | 200 µg Ab; 10 µg BP | $361.00 |